BACKGROUND: Anastomotic leakage (AL) after rectosigmoid resection is a serious complication associated with high morbidity and mortality. This case-control pilot study investigated the changes in blood concentration of 10 different cytokines and 2 complement factors in relation to symptomatic AL after low anterior resection for rectosigmoid cancer. METHODS: Fifty patients scheduled for resection of rectosigmoid cancer had blood samples taken the day before surgery and on post-operative days 1, 3 and 5. Four patients with symptomatic AL were identified. Twenty-two age- and disease-matched patients constituted the control group. The concentration of 10 cytokines (granulocyte macrophage colony-stimulating factor, interferon-γ, interleukin-1β, interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-8, interleukin-10 and tumour necrosis factor-α) and 2 complement factors (mannan-binding lectin and membrane attack complex) were measured. RESULTS: The present study demonstrated that plasma concentration of interleukin-1β, interleukin-6, interleukin-8 and interleukin 10 within the first 5 post-operative days was increased in patients who developed early clinical AL, whereas there were no changes in patients with late-onset AL. CONCLUSIONS: The demonstrated differences in the cytokine response in early and late AL may support the theory of different pathological mechanisms of AL.
BACKGROUND: Anastomotic leakage (AL) after rectosigmoid resection is a serious complication associated with high morbidity and mortality. This case-control pilot study investigated the changes in blood concentration of 10 different cytokines and 2 complement factors in relation to symptomatic AL after low anterior resection for rectosigmoid cancer. METHODS: Fifty patients scheduled for resection of rectosigmoid cancer had blood samples taken the day before surgery and on post-operative days 1, 3 and 5. Four patients with symptomatic AL were identified. Twenty-two age- and disease-matched patients constituted the control group. The concentration of 10 cytokines (granulocyte macrophage colony-stimulating factor, interferon-γ, interleukin-1β, interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-8, interleukin-10 and tumour necrosis factor-α) and 2 complement factors (mannan-binding lectin and membrane attack complex) were measured. RESULTS: The present study demonstrated that plasma concentration of interleukin-1β, interleukin-6, interleukin-8 and interleukin 10 within the first 5 post-operative days was increased in patients who developed early clinical AL, whereas there were no changes in patients with late-onset AL. CONCLUSIONS: The demonstrated differences in the cytokine response in early and late AL may support the theory of different pathological mechanisms of AL.
Authors: Nuh N Rahbari; Jürgen Weitz; Werner Hohenberger; Richard J Heald; Brendan Moran; Alexis Ulrich; Torbjörn Holm; W Douglas Wong; Emmanuel Tiret; Yoshihiro Moriya; Søren Laurberg; Marcel den Dulk; Cornelis van de Velde; Markus W Büchler Journal: Surgery Date: 2009-12-11 Impact factor: 3.982
Authors: M den Dulk; S L Noter; E R Hendriks; M A M Brouwers; C H van der Vlies; R J Oostenbroek; A G Menon; W H Steup; C J H van de Velde Journal: Eur J Surg Oncol Date: 2008-06-27 Impact factor: 4.424
Authors: Cloë L Sparreboom; Zhouqiao Wu; Adem Dereci; Geesien S A Boersema; Anand G Menon; Jiafu Ji; Gert-Jan Kleinrensink; Johan F Lange Journal: Gastroenterol Res Pract Date: 2016-03-09 Impact factor: 2.260
Authors: Marek Zawadzki; Małgorzata Krzystek-Korpacka; Andrzej Gamian; Wojciech Witkiewicz Journal: Wideochir Inne Tech Maloinwazyjne Date: 2018-01-16 Impact factor: 1.195