Literature DB >> 25147430

NEW BASE-ALTERED ADENOSINE ANALOGUES: SYNTHESIS AND AFFINITY AT ADENOSINE A1 and A2A RECEPTORS.

Seung B Ha1, Neli Melman2, Kenneth A Jacobson2, Vasu Nair1.   

Abstract

N6-Substituted adenosine analogues containing cyclic hydrazines or chiral hydroxy (ar)alkyl groups, designed to interact with the S2 and S3 receptor subregions, have been synthesized and their binding to the adenosine A1 and A2A receptors have been investigated. Examples of both types of compounds were found to exhibit highly selective binding (Ki in low nM range) to the rat A1 receptor.

Entities:  

Year:  1997        PMID： 25147430      PMCID： PMC4138058          DOI： 10.1016/S0960-894X(97)10177-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Adenosine. Renewed interest in an old drug.

Authors:  G A Pantely; J D Bristow
Journal:  Circulation       Date:  1990-11       Impact factor: 29.690

Review 2.  The cardiac effects of adenosine.

Authors:  L Belardinelli; J Linden; R M Berne
Journal:  Prog Cardiovasc Dis       Date:  1989 Jul-Aug       Impact factor: 8.194

3.  Mapping the N6-region of the adenosine A1 receptor with computer graphics.

Authors:  P J Van Galen; F J Leusen; A P IJzerman; W Soudijn
Journal:  Eur J Pharmacol       Date:  1989-03-07       Impact factor: 4.432

4.  A binding site model and structure-activity relationships for the rat A3 adenosine receptor.

Authors:  P J van Galen; A H van Bergen; C Gallo-Rodriguez; N Melman; M E Olah; A P IJzerman; G L Stiles; K A Jacobson
Journal:  Mol Pharmacol       Date:  1994-06       Impact factor: 4.436

Review 5.  Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions.

Authors:  J Linden
Journal:  Trends Pharmacol Sci       Date:  1994-08       Impact factor: 14.819

6.  Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

Authors:  Y Cheng; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1973-12-01       Impact factor: 5.858

7.  Structure-activity relationships for N6-substituted adenosines at a brain A1-adenosine receptor with a comparison to an A2-adenosine receptor regulating coronary blood flow.

Authors:  J W Daly; W Padgett; R D Thompson; S Kusachi; W J Bugni; R A Olsson
Journal:  Biochem Pharmacol       Date:  1986-08-01       Impact factor: 5.858

8.  [3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain.

Authors:  M F Jarvis; R Schulz; A J Hutchison; U H Do; M A Sills; M Williams
Journal:  J Pharmacol Exp Ther       Date:  1989-12       Impact factor: 4.030

9.  Dog coronary artery adenosine receptor: structure of the N6-alkyl subregion.

Authors:  S Kusachi; R D Thompson; W J Bugni; N Yamada; R A Olsson
Journal:  J Med Chem       Date:  1985-11       Impact factor: 7.446

Review 10.  Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.

Authors:  K A Jacobson; P J van Galen; M Williams
Journal:  J Med Chem       Date:  1992-02-07       Impact factor: 7.446
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