Simone Reppermund1, Lin Zhuang1, Wei Wen1, Melissa J Slavin1, Julian N Trollor1, Henry Brodaty1, Perminder S Sachdev1. 1. Simone Reppermund, PhD, Lin Zhuang, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Wei Wen, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney; Melissa J. Slavin, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Julian N. Trollor, MD, Centre for Healthy Brain Ageing and Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Henry Brodaty, MD, DSc, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales and Aged Care Psychiatry, Prince of Wales Hospital, Sydney; Perminder S. Sachdev, MD, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia.
Abstract
BACKGROUND: Late-life depression has been associated with white matter changes in studies using the regions of interest approach. AIMS: To investigate the cross-sectional and longitudinal relationship between white matter integrity and depression in community-dwelling individuals using diffusion tensor imaging with tract-based spatial statistics. METHOD: The sample comprised 381 participants aged between 72 and 92 years who were assessed twice within 2 years. Depressive symptoms were measured with the Geriatric Depression Scale. Tract-based spatial statistics were applied to investigate white matter integrity in currently depressed v. non-depressed elderly people and in those with a history of depression v. no history of depression. The relationship between white matter integrity and development of depressive symptoms after 2 years were analysed with logistic regression. RESULTS: Individuals with current depression had widespread white matter integrity reduction compared with non-depressed elderly people. Significant fractional anisotropy reductions were found in 45 brain areas with the most notable findings in the frontal lobe, association and projection fibres. A history of depression was not associated with reduced fractional anisotropy. White matter changes in the superior frontal gyrus, posterior thalamic radiation, superior longitudinal fasciculus and in the body of corpus callosum predicted depression at follow-up. CONCLUSIONS: Reduced white matter integrity is associated with late-life depression and predicts future depressive symptoms whereas a history of depression is not related to white matter changes. Disruption to white matter integrity may be a biomarker to predict late-life depression. Royal College of Psychiatrists.
BACKGROUND:Late-life depression has been associated with white matter changes in studies using the regions of interest approach. AIMS: To investigate the cross-sectional and longitudinal relationship between white matter integrity and depression in community-dwelling individuals using diffusion tensor imaging with tract-based spatial statistics. METHOD: The sample comprised 381 participants aged between 72 and 92 years who were assessed twice within 2 years. Depressive symptoms were measured with the Geriatric Depression Scale. Tract-based spatial statistics were applied to investigate white matter integrity in currently depressed v. non-depressed elderly people and in those with a history of depression v. no history of depression. The relationship between white matter integrity and development of depressive symptoms after 2 years were analysed with logistic regression. RESULTS: Individuals with current depression had widespread white matter integrity reduction compared with non-depressed elderly people. Significant fractional anisotropy reductions were found in 45 brain areas with the most notable findings in the frontal lobe, association and projection fibres. A history of depression was not associated with reduced fractional anisotropy. White matter changes in the superior frontal gyrus, posterior thalamic radiation, superior longitudinal fasciculus and in the body of corpus callosum predicted depression at follow-up. CONCLUSIONS: Reduced white matter integrity is associated with late-life depression and predicts future depressive symptoms whereas a history of depression is not related to white matter changes. Disruption to white matter integrity may be a biomarker to predict late-life depression. Royal College of Psychiatrists.
Authors: J E F Moonen; J C Foster-Dingley; A A van den Berg-Huijsmans; W de Ruijter; A J M de Craen; J van der Grond; R C van der Mast Journal: AJNR Am J Neuroradiol Date: 2016-09-22 Impact factor: 3.825
Authors: Miguel Germán Borda; José Manuel Santacruz; Dag Aarsland; Sandy Camargo-Casas; Carlos Alberto Cano-Gutierrez; Silvia Suárez-Monsalve; Santiago Campos-Fajardo; Mario Ulises Pérez-Zepeda Journal: Eur Geriatr Med Date: 2019-04-03 Impact factor: 1.710