Literature DB >> 25147145

Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones.

Eric B Lindgren1, Monique A de Brito2, Thatyana R A Vasconcelos1, Manuel O de Moraes3, Raquel C Montenegro4, Julliane D Yoneda5, Kátia Z Leal6.   

Abstract

Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines and theoretical profile of compounds 3o and 3p pointed them as promising lead molecules for anticancer drug design.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  (E)-2-benzothiazoles; Anticancer; Hydrazones; Lipinski's rule of five

Mesh：

Substances：

Year:  2014        PMID： 25147145     DOI： 10.1016/j.ejmech.2014.08.039

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  4 in total

1.  Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Potential in a Murine Colon Cancer Model.

Authors:  Nádia Ribeiro; Melissa Albino; Andreia Ferreira; Cristina Escrevente; Duarte C Barral; João Costa Pessoa; Catarina Pinto Reis; Maria Manuela Gaspar; Isabel Correia
Journal:  Int J Mol Sci       Date:  2022-06-16       Impact factor: 6.208

2.  Synthesis and biological evaluation of novel 6-hydroxy-benzo[d][1,3]oxathiol-2-one Schiff bases as potential anticancer agents.

Authors:  Eliza de Lucas Chazin; Paola de Souza Sanches; Eric Brazil Lindgren; Walcimar Trindade Vellasco Júnior; Laine Celestino Pinto; Rommel Mario Rodríguez Burbano; Julliane Diniz Yoneda; Kátia Zaccur Leal; Claudia Regina Brandão Gomes; James Lewis Wardell; Solange Maria Silva Veloso Wardell; Raquel Carvalho Montenegro; Thatyana Rocha Alves Vasconcelos
Journal:  Molecules       Date:  2015-01-27       Impact factor: 4.411

3.  Novel Thiazolo[5,4-b]phenothiazine Derivatives: Synthesis, Structural Characterization, and In Vitro Evaluation of Antiproliferative Activity against Human Leukaemia.

Authors:  Balazs Brem; Emese Gal; Luiza Găină; Luminiţa Silaghi-Dumitrescu; Eva Fischer-Fodor; Ciprian Ionuţ Tomuleasa; Adriana Grozav; Valentin Zaharia; Lorena Filip; Castelia Cristea
Journal:  Int J Mol Sci       Date:  2017-06-26       Impact factor: 5.923

4.  Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents.

Authors:  Derya Osmaniye; Serkan Levent; Abdullah Burak Karaduman; Sinem Ilgın; Yusuf Özkay; Zafer Asım Kaplancıklı
Journal:  Molecules       Date:  2018-05-01       Impact factor: 4.411
  4 in total

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