| Literature DB >> 25146288 |
Hamid Jafari1, Jagadish M Deshpande2, Roland W Sutter3, Sunil Bahl1, Harish Verma4, Mohammad Ahmad1, Abhishek Kunwar1, Rakesh Vishwakarma1, Ashutosh Agarwal1, Shilpi Jain5, Concepcion Estivariz6, Raman Sethi1, Natalie A Molodecky4, Nicholas C Grassly7, Mark A Pallansch6, Arani Chatterjee5, R Bruce Aylward4.
Abstract
Inactivated poliovirus vaccine (IPV) is efficacious against paralytic disease, but its effect on mucosal immunity is debated. We assessed the efficacy of IPV in boosting mucosal immunity. Participants received IPV, bivalent 1 and 3 oral poliovirus vaccine (bOPV), or no vaccine. A bOPV challenge was administered 4 weeks later, and excretion was assessed 3, 7, and 14 days later. Nine hundred and fifty-four participants completed the study. Any fecal shedding of poliovirus type 1 was 8.8, 9.1, and 13.5% in the IPV group and 14.4, 24.1, and 52.4% in the control group by 6- to 11-month, 5-year, and 10-year groups, respectively (IPV versus control: Fisher's exact test P < 0.001). IPV reduced excretion for poliovirus types 1 and 3 between 38.9 and 74.2% and 52.8 and 75.7%, respectively. Thus, IPV in OPV-vaccinated individuals boosts intestinal mucosal immunity.Entities:
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Year: 2014 PMID： 25146288 DOI： 10.1126/science.1255006
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728