Literature DB >> 25145358

Mixed messages: Re-initiation factors regulate translation of animal mRNAs.

Benedikt Obermayer1, Nikolaus Rajewsky1.   

Abstract

When ribosomes encounter upstream open reading frames (uORFs) during scanning of the 5' untranslated region (5' UTR), translation of the downstream ORF requires re-initiation. In a recent paper in Nature, Schleich et al. describe metazoan factors which specifically promote re-initiation.

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Year:  2014        PMID： 25145358      PMCID： PMC4260343          DOI： 10.1038/cr.2014.114

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

1.  GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor.

Authors:  Sergey E Dmitriev; Ilya M Terenin; Dmitri E Andreev; Pavel A Ivanov; Jacov E Dunaevsky; William C Merrick; Ivan N Shatsky
Journal:  J Biol Chem       Date:  2010-06-21       Impact factor: 5.157

2.  Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation.

Authors:  Ariel A Bazzini; Timothy G Johnstone; Romain Christiano; Sebastian D Mackowiak; Benedikt Obermayer; Elizabeth S Fleming; Charles E Vejnar; Miler T Lee; Nikolaus Rajewsky; Tobias C Walther; Antonio J Giraldez
Journal:  EMBO J       Date:  2014-04-04       Impact factor: 11.598

3.  Translational control via protein-regulated upstream open reading frames.

Authors:  Jan Medenbach; Markus Seiler; Matthias W Hentze
Journal:  Cell       Date:  2011-06-10       Impact factor: 41.582

4.  Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.

Authors:  Maxim A Skabkin; Olga V Skabkina; Vidya Dhote; Anton A Komar; Christopher U T Hellen; Tatyana V Pestova
Journal:  Genes Dev       Date:  2010-08-15       Impact factor: 11.361

5.  Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.

Authors:  Sarah E Calvo; David J Pagliarini; Vamsi K Mootha
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-16       Impact factor: 11.205

6.  Reinitiation and other unconventional posttermination events during eukaryotic translation.

Authors:  Maxim A Skabkin; Olga V Skabkina; Christopher U T Hellen; Tatyana V Pestova
Journal:  Mol Cell       Date:  2013-06-27       Impact factor: 17.970

7.  Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes.

Authors:  Nicholas T Ingolia; Liana F Lareau; Jonathan S Weissman
Journal:  Cell       Date:  2011-11-03       Impact factor: 41.582

8.  Peptidomic discovery of short open reading frame-encoded peptides in human cells.

Authors:  Sarah A Slavoff; Andrew J Mitchell; Adam G Schwaid; Moran N Cabili; Jiao Ma; Joshua Z Levin; Amir D Karger; Bogdan A Budnik; John L Rinn; Alan Saghatelian
Journal:  Nat Chem Biol       Date:  2012-11-18       Impact factor: 15.040

9.  DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth.

Authors:  Katrin Strassburger; Philipp Christoph Janiesch; Sibylle Schleich; Tatyana Koledachkina; Katharine K Miller; Katharina Haneke; Yong-Sheng Cheng; Katrin Kuechler; Georg Stoecklin; Kent E Duncan; Aurelio A Teleman
Journal:  Nature       Date:  2014-07-06       Impact factor: 49.962

Review 10.  A perspective on mammalian upstream open reading frame function.

Authors:  Joanna Somers; Tuija Pöyry; Anne E Willis
Journal:  Int J Biochem Cell Biol       Date:  2013-04-25       Impact factor: 5.085
  10 in total
  1 in total

1.  Extensive identification and analysis of conserved small ORFs in animals.

Authors:  Sebastian D Mackowiak; Henrik Zauber; Chris Bielow; Denise Thiel; Kamila Kutz; Lorenzo Calviello; Guido Mastrobuoni; Nikolaus Rajewsky; Stefan Kempa; Matthias Selbach; Benedikt Obermayer
Journal:  Genome Biol       Date:  2015-09-14       Impact factor: 13.583
  1 in total

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