| Literature DB >> 11327587 |
C Ballatore1, C McGuigan, E De Clercq, J Balzarini.
Abstract
Some novel amidate prodrugs of PMEA and PMPA have been synthesised and tested in vitro for their biological activity. Compound 5 in particular showed greatly enhanced antiviral potency compared with the parent nucleotide analogue. In vitro enzymatic studies and structure-activity relationships indicate that the degradation mechanism of such prodrugs may be the same as that described for the phosphoramidate triesters of nucleotide analogues.Entities:
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Year: 2001 PMID： 11327587 DOI： 10.1016/s0960-894x(01)00128-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823