Literature DB >> 25140927

Attitudes towards microbicide use for bacterial vaginosis in pregnancy.

Marina Catallozzi1, Camille Y Williams1, Gregory D Zimet2, Katharine M Hargreaves1, Shari E Gelber3, Adam J Ratner1, Lawrence R Stanberry1, Susan L Rosenthal1.   

Abstract

UNLABELLED: Background Bacterial vaginosis (BV) is the most common reproductive tract infection (RTI) and is a significant risk factor for preterm birth. Microbicides could be an option for the prevention and treatment of BV in pregnancy, and understanding use of the product will be crucial. The present study explored attitudes of women in the third trimester of pregnancy regarding topical microbicide use for the prevention and treatment of BV.
METHODS: Twenty-six women in their third trimester were interviewed regarding their knowledge and beliefs about RTIs during pregnancy and attitudes concerning the use of topical microbicides for prevention and treatment of BV.
RESULTS: Participants had a mean age of 24.9 years, were largely under-represented minorities and the majority had had past pregnancies. Participants had knowledge and experience with RTIs but not BV. They were open to the use of microbicides for prevention or treatment of BV, but believed that women requiring treatment would be more motivated. Rationales for acceptability were most commonly related to the baby's health. Practical issues that may interfere with use were often, but not always, related to pregnancy. There was a range of attitudes about partner involvement in decision-making and the practicalities of product use.
CONCLUSION: Pregnant women are knowledgeable about RTIs but not necessarily BV. The women in this study found microbicide use acceptable, particularly for treatment. To improve acceptability and use, education would be needed about BV and possible complications, how to overcome practical problems and the value of involving partners in the decision.

Entities:  

Year:  2014        PMID: 25140927      PMCID: PMC4482121          DOI: 10.1071/SH14011

Source DB:  PubMed          Journal:  Sex Health        ISSN: 1448-5028            Impact factor:   2.706


  43 in total

Review 1.  Biofilm formation as microbial development.

Authors:  G O'Toole; H B Kaplan; R Kolter
Journal:  Annu Rev Microbiol       Date:  2000       Impact factor: 15.500

2.  Academic achievement varies with gestational age among children born at term.

Authors:  Kimberly G Noble; William P Fifer; Virginia A Rauh; Yoko Nomura; Howard F Andrews
Journal:  Pediatrics       Date:  2012-07-02       Impact factor: 7.124

3.  Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Authors:  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; Tanuja N Gengiah; Silvia Maarschalk; Natasha Arulappan; Mukelisiwe Mlotshwa; Lynn Morris; Douglas Taylor
Journal:  Science       Date:  2010-07-19       Impact factor: 47.728

4.  Vaginal microbicide preferences among midwestern urban adolescent women.

Authors:  Amanda E Tanner; Jennifer M Katzenstein; Gregory D Zimet; Dena S Cox; Anthony D Cox; J Dennis Fortenberry
Journal:  J Adolesc Health       Date:  2008-06-05       Impact factor: 5.012

5.  DNase inhibits Gardnerella vaginalis biofilms in vitro and in vivo.

Authors:  Saul R Hymes; Tara M Randis; Thomas Yang Sun; Adam J Ratner
Journal:  J Infect Dis       Date:  2013-02-19       Impact factor: 5.226

6.  Adolescents' descriptions of the physical characteristics of microbicide surrogates and experiences of use.

Authors:  E Alexandra Zubowicz; Jennifer K Oakes; Mary B Short; Michelle M Perfect; Paul S Succop; Susan L Rosenthal
Journal:  J Womens Health (Larchmt)       Date:  2006-10       Impact factor: 2.681

Review 7.  Bacterial vaginosis: a problematic infection from both a perinatal and neonatal perspective.

Authors:  Jeff M Denney; Jennifer F Culhane
Journal:  Semin Fetal Neonatal Med       Date:  2009-04-11       Impact factor: 3.926

8.  The prevalence of bacterial vaginosis in the United States, 2001-2004; associations with symptoms, sexual behaviors, and reproductive health.

Authors:  Emilia H Koumans; Maya Sternberg; Carol Bruce; Geraldine McQuillan; Juliette Kendrick; Madeline Sutton; Lauri E Markowitz
Journal:  Sex Transm Dis       Date:  2007-11       Impact factor: 2.830

9.  Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group.

Authors:  S L Hillier; R P Nugent; D A Eschenbach; M A Krohn; R S Gibbs; D H Martin; M F Cotch; R Edelman; J G Pastorek; A V Rao
Journal:  N Engl J Med       Date:  1995-12-28       Impact factor: 91.245

10.  Treatment of asymptomatic vaginal candidiasis in pregnancy to prevent preterm birth: an open-label pilot randomized controlled trial.

Authors:  Christine L Roberts; Kristen Rickard; George Kotsiou; Jonathan M Morris
Journal:  BMC Pregnancy Childbirth       Date:  2011-03-11       Impact factor: 3.007

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