Concettina Fenga1, Silvia Gangemi, Stefania Catania, Annamaria De Luca, Chiara Costa. 1. Department of Environment, Security, Territory, Food and Health Sciences-Occupational Medicine Section, University of Messina, A.O.U. "Policlinico G. Martino"-pad. H, Via Consolare Valeria 1, 98125, Messina, Italy.
Abstract
INTRODUCTION: Altered immune function may be an indicator of increased potential for the development of immunologically based diseases such as cancer, hypersensitivity and autoimmunity. MATERIALS AND METHODS: To investigate whether Th17 and Th22 cells are targeted by pesticide exposure, we analyzed IL-17 and IL-22 serum levels in a population of 64 greenhouse workers. RESULTS AND CONCLUSION: A significant increase in IL-22 concentration was observed in serum of the exposed subjects compared to controls. These findings support the hypothesis that exposure to pesticides may reduce host defenses against infections and cancer.
INTRODUCTION: Altered immune function may be an indicator of increased potential for the development of immunologically based diseases such as cancer, hypersensitivity and autoimmunity. MATERIALS AND METHODS: To investigate whether Th17 and Th22 cells are targeted by pesticide exposure, we analyzed IL-17 and IL-22 serum levels in a population of 64 greenhouse workers. RESULTS AND CONCLUSION: A significant increase in IL-22 concentration was observed in serum of the exposed subjects compared to controls. These findings support the hypothesis that exposure to pesticides may reduce host defenses against infections and cancer.
Authors: Silvia Gangemi; Eliza Gofita; Chiara Costa; Michele Teodoro; Giusi Briguglio; Dragana Nikitovic; George Tzanakakis; Aristides M Tsatsakis; Martin F Wilks; Demetrios A Spandidos; Concettina Fenga Journal: Int J Mol Med Date: 2016-09-02 Impact factor: 4.101
Authors: Lidija Latifovic; Laura E Beane Freeman; John J Spinelli; Manisha Pahwa; Linda Kachuri; Aaron Blair; Kenneth P Cantor; Shelia Hoar Zahm; Dennis D Weisenburger; John R McLaughlin; James A Dosman; Punam Pahwa; Stella Koutros; Paul A Demers; Shelley A Harris Journal: Cancer Causes Control Date: 2020-04-20 Impact factor: 2.506
Authors: Peter D Sly; Brittany A Trottier; Catherine M Bulka; Stephania A Cormier; Julius Fobil; Rebecca C Fry; Kyoung-Woong Kim; Steven Kleeberger; Pushpam Kumar; Philip J Landrigan; Karin C Lodrop Carlsen; Antonio Pascale; Fernando Polack; Mathuros Ruchirawat; Heather J Zar; William A Suk Journal: Environ Health Date: 2021-03-26 Impact factor: 5.984