Literature DB >> 25138551

Skeletal (stromal) stem cells: an update on intracellular signaling pathways controlling osteoblast differentiation.

Basem M Abdallah1, Abbas Jafari2, Walid Zaher3, Weimin Qiu1, Moustapha Kassem4.   

Abstract

Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Dlk1; Kinases; Lrp5; MSC; Osteoblast differentiation; Pref-1

Mesh：

Year:  2014        PMID： 25138551     DOI： 10.1016/j.bone.2014.07.028

Source DB:  PubMed          Journal:  Bone        ISSN： 1873-2763            Impact factor:   4.398


  34 in total

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