Literature DB >> 31201955

The roles of Orai and Stim in bone health and disease.

Lisa J Robinson1, Harry C Blair2, John B Barnett3, Jonathan Soboloff4.   

Abstract

Orai and Stim proteins are the mediators of calcium release-activated calcium signaling and are important in the regulation of bone homeostasis and disease. This includes separate regulatory systems controlling mesenchymal stem cell differentiation to form osteoblasts, which make bone, and differentiation and regulation of osteoclasts, which resorb bone. These systems will be described separately, and their integration and relation to other systems, including Orai and Stim in teeth, will be briefly discussed at the end of this review.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Bone remodeling; Mineralization; Osteogenesis; Osteoporosis

Mesh：

Substances：

Year:  2019        PMID： 31201955      PMCID： PMC7181067          DOI： 10.1016/j.ceca.2019.06.001

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   6.817


  111 in total

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3.  Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein.

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Journal:  Mol Cell Biol       Date:  2012-05-21       Impact factor: 4.272

Review 4.  Calcium signaling in osteoclast differentiation and bone resorption.

Authors:  Hiroshi Kajiya
Journal:  Adv Exp Med Biol       Date:  2012       Impact factor: 2.622

5.  RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism.

Authors:  J Li; I Sarosi; X Q Yan; S Morony; C Capparelli; H L Tan; S McCabe; R Elliott; S Scully; G Van; S Kaufman; S C Juan; Y Sun; J Tarpley; L Martin; K Christensen; J McCabe; P Kostenuik; H Hsu; F Fletcher; C R Dunstan; D L Lacey; W J Boyle
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

6.  The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.

Authors:  Attila Mócsai; Mary Beth Humphrey; Jessica A G Van Ziffle; Yongmei Hu; Andrew Burghardt; Steven C Spusta; Sharmila Majumdar; Lewis L Lanier; Clifford A Lowell; Mary C Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-08       Impact factor: 11.205

Review 7.  A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts.

Authors:  Mary Beth Humphrey; Mary C Nakamura
Journal:  Clin Rev Allergy Immunol       Date:  2016-08       Impact factor: 8.667

8.  Hair loss and defective T- and B-cell function in mice lacking ORAI1.

Authors:  Yousang Gwack; Sonal Srikanth; Masatsugu Oh-Hora; Patrick G Hogan; Edward D Lamperti; Megumi Yamashita; Curtis Gelinas; Daniel S Neems; Yoshiteru Sasaki; Stefan Feske; Murali Prakriya; Klaus Rajewsky; Anjana Rao
Journal:  Mol Cell Biol       Date:  2008-06-30       Impact factor: 4.272

Review 9.  Regulation of Osteoblast Metabolism by Wnt Signaling.

Authors:  Megan C Moorer; Ryan C Riddle
Journal:  Endocrinol Metab (Seoul)       Date:  2018-08-14

10.  Evidence That Calcium Entry Into Calcium-Transporting Dental Enamel Cells Is Regulated by Cholecystokinin, Acetylcholine and ATP.

Authors:  Meerim K Nurbaeva; Miriam Eckstein; Arun Devotta; Jean-Pierre Saint-Jeannet; David I Yule; Michael J Hubbard; Rodrigo S Lacruz
Journal:  Front Physiol       Date:  2018-07-02       Impact factor: 4.566
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  6 in total

Review 1.  The role of TRPV channels in osteoporosis.

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Journal:  Mol Biol Rep       Date:  2021-10-25       Impact factor: 2.316

2.  The function of the calcium channel Orai1 in osteoclast development.

Authors:  Lisa J Robinson; Jonathan Soboloff; Irina L Tourkova; Quitterie C Larrouture; Michelle R Witt; Scott Gross; Robert Hooper; Elsie Samakai; Paul F Worley; John B Barnett; Harry C Blair
Journal:  FASEB J       Date:  2021-06       Impact factor: 5.834

3.  Orai3 Regulates Pancreatic Cancer Metastasis by Encoding a Functional Store Operated Calcium Entry Channel.

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4.  Orai1 downregulation causes proliferation reduction and cell cycle arrest via inactivation of the Ras-NF-κB signaling pathway in osteoblasts.

Authors:  Yunshan Guo; Jinzhu Fan; Shuguang Liu; Dingjun Hao
Journal:  BMC Musculoskelet Disord       Date:  2022-04-11       Impact factor: 2.562

5.  Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer.

Authors:  Kimi Drobin; Michal Marczyk; Martin Halle; Daniel Danielsson; Anna Papiez; Traimate Sangsuwan; Annika Bendes; Mun-Gwan Hong; Ulrika Qundos; Mats Harms-Ringdahl; Peter Wersäll; Joanna Polanska; Jochen M Schwenk; Siamak Haghdoost
Journal:  Cancers (Basel)       Date:  2020-03-22       Impact factor: 6.639

6.  Expression and Localization of Thrombospondins, Plastin 3, and STIM1 in Different Cartilage Compartments of the Osteoarthritic Varus Knee.

Authors:  Daniela Mählich; Anne Glasmacher; Ilka Müller; Johannes Oppermann; David Grevenstein; Peer Eysel; Juliane Heilig; Brunhilde Wirth; Frank Zaucke; Anja Niehoff
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  6 in total

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