| Literature DB >> 25134534 |
Kexin Chen1, Hongxia Ma2, Lian Li1, Rongyu Zang3, Cheng Wang4, Fengju Song5, Tingyan Shi6, Dianke Yu7, Ming Yang8, Wenqiong Xue9, Juncheng Dai4, Shuang Li10, Hong Zheng5, Chen Wu7, Ying Zhang9, Xiaohua Wu11, Dake Li12, Fengxia Xue13, Haixin Li5, Zhi Jiang14, Jibin Liu15, Yuexin Liu16, Pei Li5, Wen Tan7, Jing Han4, Jiang Jie4, Quan Hao17, Zhibin Hu4, Dongxin Lin7, Ding Ma10, Weihua Jia9, Hongbing Shen4, Qingyi Wei18.
Abstract
Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (P(meta)<10(-4)) in 960 EOC cases and 1,799 controls (stage II), and an additional 492 EOC cases and 1,004 controls (stage III). Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages). These results may advance our understanding of genetic susceptibility to EOC.Entities:
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Year: 2014 PMID： 25134534 DOI： 10.1038/ncomms5682
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919