OBJECTIVE: To determine the frequency of aortic arch calcification and it's relationship with procedural times, angiographic recanalization, and discharge outcomes in acute ischemic stroke patients undergoing endovascular treatment. METHODS: The thoracic component of computed tomographic (CT) angiogram were reviewed by an independent reviewer to determine presence of any calcification; and the severity of calcification was graded as follows: mild, single small calcifications; moderate, multiple small calcifications; or severe, one or more large calcifications. RESULTS: Aortic arch calcification was present in 120 (62.4%) of 188 patients and severity was graded as mild (n=24), moderate (n=44), and severe (n=52). Compared with patients without calcification, the mean intracranial access time (minutes ± SD) was similar among patients with aortic arch calcification (70 ± 31 versus 64 ± 31, p=0.9). The mean time intracranial access time increased with increasing severity of aortic arch calcification (61±27, 67±29, and 74±34, p=0.3). Patients with aortic arch calcification had similar rates of complete or partial recanalization [85 (71%) versus 50 (76%)], p=0.6) but lower rates of favorable outcomes [modified Rankin scale 0-2] at discharge 27 (22%) versus 26 (39%), p=0.02). CONCLUSIONS: A high proportion of acute ischemic stroke patients have aortic arch calcification which is associated with lower rates of favorable outcome following endovascular treatment. ABBREVIATIONS: SDstandard deviationICHintracerebral hemorrhageNIHSSNational Institutes of Health Stroke ScaleTIAtransient ischemic attackICHintracerebral hemorrhagemRSmodified Rankin scale.
OBJECTIVE: To determine the frequency of aortic arch calcification and it's relationship with procedural times, angiographic recanalization, and discharge outcomes in acute ischemic strokepatients undergoing endovascular treatment. METHODS: The thoracic component of computed tomographic (CT) angiogram were reviewed by an independent reviewer to determine presence of any calcification; and the severity of calcification was graded as follows: mild, single small calcifications; moderate, multiple small calcifications; or severe, one or more large calcifications. RESULTS:Aortic arch calcification was present in 120 (62.4%) of 188 patients and severity was graded as mild (n=24), moderate (n=44), and severe (n=52). Compared with patients without calcification, the mean intracranial access time (minutes ± SD) was similar among patients with aortic arch calcification (70 ± 31 versus 64 ± 31, p=0.9). The mean time intracranial access time increased with increasing severity of aortic arch calcification (61±27, 67±29, and 74±34, p=0.3). Patients with aortic arch calcification had similar rates of complete or partial recanalization [85 (71%) versus 50 (76%)], p=0.6) but lower rates of favorable outcomes [modified Rankin scale 0-2] at discharge 27 (22%) versus 26 (39%), p=0.02). CONCLUSIONS: A high proportion of acute ischemic strokepatients have aortic arch calcification which is associated with lower rates of favorable outcome following endovascular treatment. ABBREVIATIONS: SDstandard deviationICHintracerebral hemorrhageNIHSSNational Institutes of Health Stroke ScaleTIAtransient ischemic attackICHintracerebral hemorrhagemRSmodified Rankin scale.
Authors: Suzette E Elias-Smale; Arlette E Odink; Renske G Wieberdink; Albert Hofman; Myriam G M Hunink; Gabriel P Krestin; Peter J Koudstaal; Monique M B Breteler; Aad van der Lugt; Jacqueline C M Witteman Journal: Atherosclerosis Date: 2010-06-30 Impact factor: 5.162
Authors: Kyung-Hee Cho; Deok Hee Lee; Sun U Kwon; Choong Gon Choi; Sang Joon Kim; Dae-Chul Suh; Jong S Kim; Dong-Wha Kang Journal: Cerebrovasc Dis Date: 2012-01-19 Impact factor: 2.762
Authors: Arlette E Odink; Aad van der Lugt; Albert Hofman; Myriam G M Hunink; Monique M B Breteler; Gabriel P Krestin; Jacqueline C M Witteman Journal: Atherosclerosis Date: 2006-08-21 Impact factor: 5.162
Authors: Ronil V Chandra; Thabele M Leslie-Mazwi; Daniel C Oh; Zeshan A Chaudhry; Brijesh P Mehta; Natalia S Rost; James D Rabinov; Joshua A Hirsch; R Gilberto González; Lee H Schwamm; Albert J Yoo Journal: Stroke Date: 2012-06-28 Impact factor: 7.914