| Literature DB >> 25131931 |
Jianwei Li1, Feng Tian1, Dajiang Li1, Jian Chen1, Peng Jiang1, Shuguo Zheng1, Xiaowu Li1, Shuguang Wang2.
Abstract
The aberrant expression of PSMD10 has important functions in various malignancies. This study showed that PSMD10 was highly expressed and inversely correlated with the expression of miR-605 in intrahepatic cholangiocarcinoma (ICC) specimens. MiR-605 directly targeted and repressed PSMD10 expression. In addition, over-expression of miR-605 inhibited ICC cell progression both in vitro and in vivo. This effect of miR-605 on ICC cells was similar to that of PSMD10 knock-down by RNAi. Moreover, restoration of PSMD10 could reverse the phenotypic alteration caused by miR-605 in ICC cells. These results suggest a new therapeutic strategy in ICC by restoring miR-605, which is regulated by p53.Entities:
Keywords: Apoptosis; Intrahepatic cholangiocarcinoma; Invasion; Proteasome 26S subunit non-ATPase 10; miR-605
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Year: 2014 PMID： 25131931 DOI： 10.1016/j.febslet.2014.08.008
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124