| Literature DB >> 25128426 |
Yongyu Yang1, Xiding Yang2, Bing Xu3, Guangyao Zeng2, Jianbing Tan2, Xi He2, Changping Hu4, YingJun Zhou5.
Abstract
Mulberry leaf, an important traditional Chinese medicine, possesses many biological activities, including effects of anti-obesity. However, which constituents of mulberry leaf are responsible for its anti-adipogenic action is unclear. This study primarily investigated the chemical constituents from mulberry leaf and their bioactivity on the proliferation and differentiation of 3T3-L1 preadipocytes. A new flavane derivative, (2S)-4'-hydroxy-7-methoxy-8-prenylflavan (1), together with twelve known compounds including three flavanes (2-4), three chalcones (5-7), two flavones (8-9), two benzofurans (10-11) and two coumarin (12-13) was isolated from mulberry leaf. The structure of the new compound was elucidated by various spectroscopic methods including UV, HR-ESI-MS, (1)H and (13)C NMR and CD. The results of activity screening showed that compound 2, 6 and 7 inhibited the proliferation and differentiation of 3T3-L1 preadipocytes.Entities:
Keywords: (2S)-4′-hydroxy-7-methoxy-8-prenylflavan; (2S)-4′-hydroxy-7-methoxy-8-prenylflavan (PubChem CID: No CID); 2′,4′-Dihydroxy-7′-methoxy-8-prenylflavan (PubChem CID: No CID); 2′,7-Dihydroxy-4′-methoxy-8-prenylflavan (PubChem CID: No CID); 3T3-L1 preadipocyte; 7-Hydroxy-6-methoxycoumarin (PubChem CID: 5280460); 7-Hydroxycoumarin (PubChem CID: 5281426); Astragalin (PubChem CID: 5282102); Brosimine B (PubChem CID: No CID); Flavane derivative; Isobavachalcone (PubChem CID: 5281255); Isoquercitrin (PubChem CID: 5280804); Morachalcone A (PubChem CID: 9862769); Morachalcone B (PubChem CID: No CID); Moracin C (PubChem CID: 155248); Moracin M (PubChem CID: 185848); Mulberry leaf; Obesity
Mesh：
Year: 2014 PMID： 25128426 DOI： 10.1016/j.fitote.2014.08.010
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882