| Literature DB >> 2512641 |
T Yamamori1, K Fukada, R Aebersold, S Korsching, M J Fann, P H Patterson.
Abstract
A protein secreted by cultured rat heart cells can direct the choice of neurotransmitter phenotype made by cultured rat sympathetic neurons. Structural analysis and biological assays demonstrated that this protein is identical to a protein that regulates the growth and differentiation of embryonic stem cells and myeloid cells, and that stimulates bone remodeling and acute-phase protein synthesis in hepatocytes. This protein has been termed D factor, DIA, DIF, DRF, HSFIII, and LIF. Thus, this cytokine, like IL-6 and TGF beta, regulates growth and differentiation in the embryo and in the adult in many tissues, now including the nervous system.Entities:
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Year: 1989 PMID： 2512641 DOI： 10.1126/science.2512641
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728