J C Denny1. 1. Joshua C. Denny, MD, MS, 2525 West End Ave - Suite 672, Nashville, TN 37213, USA, E-mail: josh.denny@vanderbilt.edu.
Abstract
OBJECTIVE: To provide a survey of recent progress in the use of large-scale biologic data to impact clinical care, and the impact the reuse of electronic health record data has made in genomic discovery. METHOD: Survey of key themes in translational bioinformatics, primarily from 2012 and 2013. RESULT: This survey focuses on four major themes: the growing use of Electronic Health Records (EHRs) as a source for genomic discovery, adoption of genomics and pharmacogenomics in clinical practice, the possible use of genomic technologies for drug repurposing, and the use of personal genomics to guide care. CONCLUSION: Reuse of abundant clinical data for research is speeding discovery, and implementation of genomic data into clinical medicine is impacting care with new classes of data rarely used previously in medicine.
OBJECTIVE: To provide a survey of recent progress in the use of large-scale biologic data to impact clinical care, and the impact the reuse of electronic health record data has made in genomic discovery. METHOD: Survey of key themes in translational bioinformatics, primarily from 2012 and 2013. RESULT: This survey focuses on four major themes: the growing use of Electronic Health Records (EHRs) as a source for genomic discovery, adoption of genomics and pharmacogenomics in clinical practice, the possible use of genomic technologies for drug repurposing, and the use of personal genomics to guide care. CONCLUSION: Reuse of abundant clinical data for research is speeding discovery, and implementation of genomic data into clinical medicine is impacting care with new classes of data rarely used previously in medicine.
Keywords:
Translational bioinformatics; big data; electronic health records; genomics; personalized medicine
Authors: Philippe Sanseau; Pankaj Agarwal; Michael R Barnes; Tomi Pastinen; J Brent Richards; Lon R Cardon; Vincent Mooser Journal: Nat Biotechnol Date: 2012-04-10 Impact factor: 54.908
Authors: Lucia A Hindorff; Praveen Sethupathy; Heather A Junkins; Erin M Ramos; Jayashri P Mehta; Francis S Collins; Teri A Manolio Journal: Proc Natl Acad Sci U S A Date: 2009-05-27 Impact factor: 11.205
Authors: Enrico Tiacci; Vladimir Trifonov; Gianluca Schiavoni; Antony Holmes; Wolfgang Kern; Maria Paola Martelli; Alessandra Pucciarini; Barbara Bigerna; Roberta Pacini; Victoria A Wells; Paolo Sportoletti; Valentina Pettirossi; Roberta Mannucci; Oliver Elliott; Arcangelo Liso; Achille Ambrosetti; Alessandro Pulsoni; Francesco Forconi; Livio Trentin; Gianpietro Semenzato; Giorgio Inghirami; Monia Capponi; Francesco Di Raimondo; Caterina Patti; Luca Arcaini; Pellegrino Musto; Stefano Pileri; Claudia Haferlach; Susanne Schnittger; Giovanni Pizzolo; Robin Foà; Laurent Farinelli; Torsten Haferlach; Laura Pasqualucci; Raul Rabadan; Brunangelo Falini Journal: N Engl J Med Date: 2011-06-11 Impact factor: 91.245
Authors: W-Q Wei; Q Feng; L Jiang; M S Waitara; O F Iwuchukwu; D M Roden; M Jiang; H Xu; R M Krauss; J I Rotter; D A Nickerson; R L Davis; R L Berg; P L Peissig; C A McCarty; R A Wilke; J C Denny Journal: Clin Pharmacol Ther Date: 2013-10-04 Impact factor: 6.875
Authors: Mary Regina Boland; George Hripcsak; David J Albers; Ying Wei; Adam B Wilcox; Jin Wei; Jianhua Li; Steven Lin; Michael Breene; Ronnie Myers; John Zimmerman; Panos N Papapanou; Chunhua Weng Journal: J Clin Periodontol Date: 2013-03-15 Impact factor: 8.728
Authors: Joshua C Denny; Marylyn D Ritchie; Melissa A Basford; Jill M Pulley; Lisa Bastarache; Kristin Brown-Gentry; Deede Wang; Dan R Masys; Dan M Roden; Dana C Crawford Journal: Bioinformatics Date: 2010-03-24 Impact factor: 6.937
Authors: P H O'Donnell; A Bush; J Spitz; K Danahey; D Saner; S Das; N J Cox; M J Ratain Journal: Clin Pharmacol Ther Date: 2012-08-29 Impact factor: 6.875
Authors: Erica Bowton; Julie R Field; Sunny Wang; Jonathan S Schildcrout; Sara L Van Driest; Jessica T Delaney; James Cowan; Peter Weeke; Jonathan D Mosley; Quinn S Wells; Jason H Karnes; Christian Shaffer; Josh F Peterson; Joshua C Denny; Dan M Roden; Jill M Pulley Journal: Sci Transl Med Date: 2014-04-30 Impact factor: 17.956
Authors: Joyce Y Tung; Chuong B Do; David A Hinds; Amy K Kiefer; J Michael Macpherson; Arnab B Chowdry; Uta Francke; Brian T Naughton; Joanna L Mountain; Anne Wojcicki; Nicholas Eriksson Journal: PLoS One Date: 2011-08-17 Impact factor: 3.240
Authors: Timothy M Herr; Suzette J Bielinski; Erwin Bottinger; Ariel Brautbar; Murray Brilliant; Christopher G Chute; Beth L Cobb; Joshua C Denny; Hakon Hakonarson; Andrea L Hartzler; George Hripcsak; Joseph Kannry; Isaac S Kohane; Iftikhar J Kullo; Simon Lin; Shannon Manzi; Keith Marsolo; Casey Lynnette Overby; Jyotishman Pathak; Peggy Peissig; Jill Pulley; James Ralston; Luke Rasmussen; Dan M Roden; Gerard Tromp; Timothy Uphoff; Chunhua Weng; Wendy Wolf; Marc S Williams; Justin Starren Journal: J Pathol Inform Date: 2015-09-28