Literature DB >> 25122865

Mutational analysis of Pneumocystis jirovecii dihydropteroate synthase and dihydrofolate reductase genes in HIV-infected patients in China.

Xilong Deng1, Li Zhuo2, Yun Lan3, Zhaoxia Dai2, Wan-shan Chen3, Weiping Cai2, Joseph A Kovacs4, Liang Ma4, Xiaoping Tang5.   

Abstract

We investigated Pneumocystis jirovecii dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) genes for mutations in 25 Chinese HIV-infected patients with P. jirovecii pneumonia. We identified DHPS mutations in 3 (12%) patients and DHFR mutations in 1 (4%) patient. The prevalence of DHPS and DHFR mutations in China remains low, as it does in other developing countries.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25122865      PMCID： PMC4313241          DOI： 10.1128/JCM.01848-14

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  14 in total

1.  Genotypes of Pneumocystis jiroveci isolates obtained in Harare, Zimbabwe, and London, United Kingdom.

Authors:  Robert F Miller; Austin R Lindley; Helen E Ambrose; Adam S Malin; Ann E Wakefield
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

2.  Absence of dihydropteroate synthase mutations in Pneumocystis jirovecii from Brazilian AIDS patients.

Authors:  Gustavo Wissmann; Míriam J Alvarez-Martinez; Steven R Meshnick; Ada R S Dihel; João C Prolla
Journal:  J Eukaryot Microbiol       Date:  2006 Jul-Aug       Impact factor: 3.346

3.  Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use.

Authors:  L Ma; L Borio; H Masur; J A Kovacs
Journal:  J Infect Dis       Date:  1999-12       Impact factor: 5.226

4.  Genetic characterization of the dihydrofolate reductase gene of Pneumocystis jirovecii isolates from Portugal.

Authors:  Marina C Costa; Francisco Esteves; Francisco Antunes; Olga Matos
Journal:  J Antimicrob Chemother       Date:  2006-10-12       Impact factor: 5.790

5.  Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f. sp. hominis in Japan.

Authors:  Takashi Takahashi; Tokiomi Endo; Tetsuya Nakamura; Hiroyuki Sakashita; Kyoko Kimura; Kenji Ohnishi; Yoshihiro Kitamura; Aikichi Iwamoto
Journal:  J Med Microbiol       Date:  2002-06       Impact factor: 2.472

6.  Association between a specific Pneumocystis jiroveci dihydropteroate synthase mutation and failure of pyrimethamine/sulfadoxine prophylaxis in human immunodeficiency virus-positive and -negative patients.

Authors:  Aimable Nahimana; Meja Rabodonirina; Giorgio Zanetti; Isabelle Meneau; Patrick Francioli; Jacques Bille; Philippe M Hauser
Journal:  J Infect Dis       Date:  2003-09-26       Impact factor: 5.226

7.  Dihydropteroate synthase and novel dihydrofolate reductase gene mutations in strains of Pneumocystis jirovecii from South Africa.

Authors:  F J L Robberts; L J Chalkley; K Weyer; P Goussard; L D Liebowitz
Journal:  J Clin Microbiol       Date:  2005-03       Impact factor: 5.948

8.  Increase in prevalence of Pneumocystis carinii mutations in patients with AIDS and P. carinii pneumonia, in the United States and China.

Authors:  Powel H Kazanjian; David Fisk; Wendy Armstrong; Qin Shulin; Hua Liwei; Zhang Ke; Steven Meshnick
Journal:  J Infect Dis       Date:  2004-04-15       Impact factor: 5.226

9.  Prevalence of dihydropteroate synthase mutants in HIV-infected South African children with Pneumocystis jiroveci pneumonia.

Authors:  H J Zar; M J Alvarez-Martinez; A Harrison; S R Meshnick
Journal:  Clin Infect Dis       Date:  2004-09-07       Impact factor: 9.079

10.  Clinical epidemiology of HIV/AIDS in China from 2004-2011.

Authors:  Min Li; Yinzhong Shen; Xiaofei Jiang; Qi Li; Xiaoming Zhou; Hongzhou Lu
Journal:  Biosci Trends       Date:  2014-02       Impact factor: 2.400
View more
  4 in total

1.  Pneumocystis jirovecii infection and the associated dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) mutations in HIV-positive individuals from Pune, India.

Authors:  Arati Mane; Pankaj Gujar; Jipsi Chandra; Rahul Lokhande; Tilak Dhamgaye; Shivhari Ghorpade; Arun Risbud
Journal:  Mycopathologia       Date:  2014-09-30       Impact factor: 2.574

2.  Genetic Polymorphisms of Pneumocystis jirovecii in HIV-Positive and HIV-Negative Patients in Northern China.

Authors:  Ting Xue; Wei-Qin Du; Wen-Juan Dai; Yi-Shan Li; Shu-Feng Wang; Jun-Ling Wang; Xin-Ri Zhang
Journal:  Pol J Microbiol       Date:  2022-02-23

Review 3.  Epidemiology of fungal infections in China.

Authors:  Min Chen; Yuan Xu; Nan Hong; Yali Yang; Wenzhi Lei; Lin Du; Jingjun Zhao; Xia Lei; Lin Xiong; Langqi Cai; Hui Xu; Weihua Pan; Wanqing Liao
Journal:  Front Med       Date:  2018-01-11       Impact factor: 4.592

Review 4.  A Molecular Window into the Biology and Epidemiology of Pneumocystis spp.

Authors:  Liang Ma; Ousmane H Cissé; Joseph A Kovacs
Journal:  Clin Microbiol Rev       Date:  2018-06-13       Impact factor: 26.132
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.