Literature DB >> 15750128

Dihydropteroate synthase and novel dihydrofolate reductase gene mutations in strains of Pneumocystis jirovecii from South Africa.

F J L Robberts1, L J Chalkley, K Weyer, P Goussard, L D Liebowitz.   

Abstract

Dihydropteroate synthase (DHPS) gene mutations have raised concerns about emerging sulfonamide resistance in Pneumocystis jirovecii. DHPS and dihydrofolate reductase (DHFR) gene products were amplified in clinical specimens from South African patients. One of 53 DHPS genes sequenced contained the double mutation Thr55Ala Pro57Ser. DHFR gene mutations detected were Ala67Val and the new mutations Arg59Gly and C278T.

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Year:  2005        PMID： 15750128      PMCID： PMC1081295          DOI： 10.1128/JCM.43.3.1443-1444.2005

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  18 in total

1.  Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia.

Authors:  J Helweg-Larsen; T L Benfield; J Eugen-Olsen; J D Lundgren; B Lundgren
Journal:  Lancet       Date:  1999-10-16       Impact factor: 79.321

2.  Prospective study of etiologic agents of community-acquired pneumonia in patients with HIV infection.

Authors:  D Rimland; T R Navin; J L Lennox; J A Jernigan; J Kaplan; D Erdman; C J Morrison; S P Wahlquist
Journal:  AIDS       Date:  2002-01-04       Impact factor: 4.177

3.  The high burden of Pneumocystis carinii pneumonia in African HIV-1-infected children hospitalized for severe pneumonia.

Authors:  Donatella D Ruffini; Shabir A Madhi
Journal:  AIDS       Date:  2002-01-04       Impact factor: 4.177

4.  Mutations in dihydropteroate synthase gene of Pneumocystis carinii in HIV patients with Pneumocystis carinii pneumonia.

Authors:  E Visconti; E Ortona; P Mencarini; P Margutti; S Marinaci; M Zolfo; A Siracusano; E Tamburrini
Journal:  Int J Antimicrob Agents       Date:  2001-12       Impact factor: 5.283

5.  Pneumocystis carinii pneumonia in HIV infected patients from South Africa.

Authors:  A G Mahomed; J Murray; S Klempman; G Richards; C Feldman; N T Levy; C Smith; J Kallenbach
Journal:  East Afr Med J       Date:  1999-02

6.  Relationship between mutations in dihydropteroate synthase of Pneumocystis carinii f. sp. hominis isolates in Japan and resistance to sulfonamide therapy.

Authors:  T Takahashi; N Hosoya; T Endo; T Nakamura; H Sakashita; K Kimura; K Ohnishi; Y Nakamura; A Iwamoto
Journal:  J Clin Microbiol       Date:  2000-09       Impact factor: 5.948

7.  Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene.

Authors:  L Huang; C B Beard; J Creasman; D Levy; J S Duchin; S Lee; N Pieniazek; J L Carter; C del Rio; D Rimland; T R Navin
Journal:  J Infect Dis       Date:  2000-09-08       Impact factor: 5.226

8.  Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f. sp. hominis in Japan.

Authors:  Takashi Takahashi; Tokiomi Endo; Tetsuya Nakamura; Hiroyuki Sakashita; Kyoko Kimura; Kenji Ohnishi; Yoshihiro Kitamura; Aikichi Iwamoto
Journal:  J Med Microbiol       Date:  2002-06       Impact factor: 2.472

9.  Association between a specific Pneumocystis jiroveci dihydropteroate synthase mutation and failure of pyrimethamine/sulfadoxine prophylaxis in human immunodeficiency virus-positive and -negative patients.

Authors:  Aimable Nahimana; Meja Rabodonirina; Giorgio Zanetti; Isabelle Meneau; Patrick Francioli; Jacques Bille; Philippe M Hauser
Journal:  J Infect Dis       Date:  2003-09-26       Impact factor: 5.226

10.  Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.

Authors:  C B Beard; J L Carter; S P Keely; L Huang; N J Pieniazek; I N Moura; J M Roberts; A W Hightower; M S Bens; A R Freeman; S Lee; J R Stringer; J S Duchin; C del Rio; D Rimland; R P Baughman; D A Levy; V J Dietz; P Simon; T R Navin
Journal:  Emerg Infect Dis       Date:  2000 May-Jun       Impact factor: 6.883
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  7 in total

1.  High prevalence of dihydropteroate synthase mutations in Pneumocystis jirovecii isolated from patients with Pneumocystis pneumonia in South Africa.

Authors:  Leigh Dini; Mignon du Plessis; John Frean; Victor Fernandez
Journal:  J Clin Microbiol       Date:  2010-03-29       Impact factor: 5.948

2.  Mutational analysis of Pneumocystis jirovecii dihydropteroate synthase and dihydrofolate reductase genes in HIV-infected patients in China.

Authors:  Xilong Deng; Li Zhuo; Yun Lan; Zhaoxia Dai; Wan-shan Chen; Weiping Cai; Joseph A Kovacs; Liang Ma; Xiaoping Tang
Journal:  J Clin Microbiol       Date:  2014-08-13       Impact factor: 5.948

Review 3.  HIV-associated Pneumocystis pneumonia.

Authors:  Laurence Huang; Adithya Cattamanchi; J Lucian Davis; Saskia den Boon; Joseph Kovacs; Steven Meshnick; Robert F Miller; Peter D Walzer; William Worodria; Henry Masur
Journal:  Proc Am Thorac Soc       Date:  2011-06

4.  Absence of dihydropteroate synthase gene mutations in Pneumocystis jirovecii strains isolated from Aegean region of Turkey.

Authors:  Soykan Ozkoc; Ceren Erguden; Songul Bayram Delibas
Journal:  Parasitol Res       Date:  2018-07-19       Impact factor: 2.289

5.  Trimethoprim resistance of dihydrofolate reductase variants from clinical isolates of Pneumocystis jirovecii.

Authors:  S F Queener; V Cody; J Pace; P Torkelson; A Gangjee
Journal:  Antimicrob Agents Chemother       Date:  2013-07-29       Impact factor: 5.191

Review 6.  Epidemiology of fungal infections in China.

Authors:  Min Chen; Yuan Xu; Nan Hong; Yali Yang; Wenzhi Lei; Lin Du; Jingjun Zhao; Xia Lei; Lin Xiong; Langqi Cai; Hui Xu; Weihua Pan; Wanqing Liao
Journal:  Front Med       Date:  2018-01-11       Impact factor: 4.592

Review 7.  A Molecular Window into the Biology and Epidemiology of Pneumocystis spp.

Authors:  Liang Ma; Ousmane H Cissé; Joseph A Kovacs
Journal:  Clin Microbiol Rev       Date:  2018-06-13       Impact factor: 26.132
  7 in total

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