Literature DB >> 25122525

Tracheal tissue engineering in rats.

Philipp Jungebluth1, Johannes C Haag1, Sebastian Sjöqvist1, Ylva Gustafsson1, Antonio Beltrán Rodríguez1, Costantino Del Gaudio2, Alessandra Bianco2, Ivar Dehnisch3, Per Uhlén3, Silvia Baiguera1, Greg Lemon1, Mei Ling Lim1, Paolo Macchiarini1.   

Abstract

Tissue-engineered tracheal transplants have been successfully performed clinically. However, before becoming a routine clinical procedure, further preclinical studies are necessary to determine the underlying mechanisms of in situ tissue regeneration. Here we describe a protocol using a tissue engineering strategy and orthotopic transplantation of either natural decellularized donor tracheae or artificial electrospun nanofiber scaffolds into a rat model. The protocol includes details regarding how to assess the scaffolds' biomechanical properties and cell viability before implantation. It is a reliable and reproducible model that can be used to investigate the crucial aspects and pathways of in situ tracheal tissue restoration and regeneration. The model can be established in <6 months, and it may also provide a means to investigate cell-surface interactions, cell differentiation and stem cell fate.

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Year:  2014        PMID： 25122525     DOI： 10.1038/nprot.2014.149

Source DB:  PubMed          Journal:  Nat Protoc        ISSN： 1750-2799            Impact factor:   13.491


  28 in total

1.  Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue.

Authors:  Johannes Haag; Silvia Baiguera; Philipp Jungebluth; Daniel Barale; Costantino Del Gaudio; Francesca Castiglione; Alessandra Bianco; Camilla E Comin; Domenico Ribatti; Paolo Macchiarini
Journal:  Biomaterials       Date:  2011-10-24       Impact factor: 12.479

2.  Verification of cell viability in bioengineered tissues and organs before clinical transplantation.

Authors:  Philipp Jungebluth; Johannes C Haag; Mei L Lim; Greg Lemon; Sebastian Sjöqvist; Ylva Gustafsson; Fatemeh Ajalloueian; Irina Gilevich; Oscar E Simonson; Karl H Grinnemo; Matthias Corbascio; Silvia Baiguera; Costantino Del Gaudio; Staffan Strömblad; Paolo Macchiarini
Journal:  Biomaterials       Date:  2013-03-06       Impact factor: 12.479

3.  Tracheal replacement with autologous esophagus for tracheal stricture.

Authors:  E W Fonkalsrud; S Sumida
Journal:  Arch Surg       Date:  1971-02

4.  Experimental tracheal and tracheoesophageal allotransplantation. Paris-Sud University Lung Transplantation Group.

Authors:  P Macchiarini; G M Mazmanian; V de Montpréville; E Dulmet; M Fattal; B Lenot; A Chapelier; P Dartevelle
Journal:  J Thorac Cardiovasc Surg       Date:  1995-10       Impact factor: 5.209

5.  Replacement of a tracheal stenosis with a tissue-engineered human trachea using autologous stem cells: a case report.

Authors:  Malin Berg; Hasse Ejnell; Anikó Kovács; Nikhil Nayakawde; Pradeep B Patil; Meghnad Joshi; Luaay Aziz; Göran Rådberg; Shahin Hajizadeh; Michael Olausson; Suchitra Sumitran-Holgersson
Journal:  Tissue Eng Part A       Date:  2013-10-12       Impact factor: 3.845

6.  Transplantation of the cryopreserved tracheal allograft in growing rabbits: effect of immunosuppressant.

Authors:  Chieko Hisamatsu; Kosaku Maeda; Hiroshi Tanaka; Yutaka Okita
Journal:  Pediatr Surg Int       Date:  2006-11       Impact factor: 1.827

7.  Tissue engineered human tracheas for in vivo implantation.

Authors:  Silvia Baiguera; Phillip Jungebluth; Alan Burns; Carmelo Mavilia; Johannes Haag; Paolo De Coppi; Paolo Macchiarini
Journal:  Biomaterials       Date:  2010-08-25       Impact factor: 12.479

8.  One-stage allotransplantation of thoracic segment of the trachea in a patient with idiopathic fibrosing mediastinitis and marked tracheal stenosis.

Authors:  P K Yablonsky; S M Cherny; S V Orlov; B B Shafirovsky; I M Kuznetzov
Journal:  Eur J Cardiothorac Surg       Date:  1993       Impact factor: 4.191

9.  The first tissue-engineered airway transplantation: 5-year follow-up results.

Authors:  Alessandro Gonfiotti; Massimo O Jaus; Daniel Barale; Silvia Baiguera; Camilla Comin; Federico Lavorini; Giovanni Fontana; Oriol Sibila; Giovanni Rombolà; Philipp Jungebluth; Paolo Macchiarini
Journal:  Lancet       Date:  2013-10-23       Impact factor: 79.321

10.  Cryopreserved, irradiated tracheal homograft transplantation for laryngotracheal reconstruction in human beings.

Authors:  S Kunachak; B Kulapaditharom; Y Vajaradul; M Rochanawutanon
Journal:  Otolaryngol Head Neck Surg       Date:  2000-06       Impact factor: 5.591
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  7 in total

Review 1.  Design and application of 'J-shaped' stress-strain behavior in stretchable electronics: a review.

Authors:  Yinji Ma; Xue Feng; John A Rogers; Yonggang Huang; Yihui Zhang
Journal:  Lab Chip       Date:  2017-05-16       Impact factor: 6.799

2.  Long-term outcomes of patch tracheoplasty using collagenous tissue membranes (biosheets) produced by in-body tissue architecture in a beagle model.

Authors:  Satoshi Umeda; Yasuhide Nakayama; Takeshi Terazawa; Ryosuke Iwai; Shohei Hiwatashi; Kengo Nakahata; Yuichi Takama; Hiroomi Okuyama
Journal:  Surg Today       Date:  2019-05-16       Impact factor: 2.549

Review 3.  Recreating composition, structure, functionalities of tissues at nanoscale for regenerative medicine.

Authors:  Emine Alarçin; Xiaofei Guan; Sara Saheb Kashaf; Khairat Elbaradie; Huazhe Yang; Hae Lin Jang; Ali Khademhosseini
Journal:  Regen Med       Date:  2016-11-25       Impact factor: 3.806

4.  Designing a tissue-engineered tracheal scaffold for preclinical evaluation.

Authors:  Cameron A Best; Victoria K Pepper; Devan Ohst; Kyle Bodnyk; Eric Heuer; Ekene A Onwuka; Nakesha King; Robert Strouse; Jonathan Grischkan; Christopher K Breuer; Jed Johnson; Tendy Chiang
Journal:  Int J Pediatr Otorhinolaryngol       Date:  2017-11-22       Impact factor: 1.675

5.  Clinic application of tissue engineered bronchus for lung cancer treatment.

Authors:  Qiang Tan; Ruijun Liu; Xiaoke Chen; Jingxiang Wu; Yinggen Pan; Shun Lu; Walter Weder; Qingquan Luo
Journal:  J Thorac Dis       Date:  2017-01       Impact factor: 2.895

6.  A Comparative Study of the Effects of Different Decellularization Methods and Genipin-Cross-Linking on the Properties of Tracheal Matrices.

Authors:  Yi Zhong; Ai Jiang; Fei Sun; Yuanfan Xiao; Ying Gu; Lei Wu; Yujie Zhang; Hongcan Shi
Journal:  Tissue Eng Regen Med       Date:  2018-12-08       Impact factor: 4.169

Review 7.  Tissue engineering applications in otolaryngology-The state of translation.

Authors:  Weston L Niermeyer; Cole Rodman; Michael M Li; Tendy Chiang
Journal:  Laryngoscope Investig Otolaryngol       Date:  2020-06-19
  7 in total

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