Géraldine Petit1, Charles Kornreich1, Bernard Dan1, Paul Verbanck1, Salvatore Campanella2. 1. Laboratory of Psychological Medicine and Addictology, Université Libre de Bruxelles (ULB), Brussels, Belgium. 2. Laboratory of Psychological Medicine and Addictology, Université Libre de Bruxelles (ULB), Brussels, Belgium salvatore.campanella@chu-brugmann.be.
Abstract
BACKGROUND: The continuation of binge drinking is associated with the development of neurocognitive brain abnormalities similar to those observed in patients with alcohol dependence. Alcohol cue reactivity constitutes a risk marker for alcohol dependence. Through event-related potentials (ERPs), we aimed to examine its potential presence as well as its evolution over time in binge drinkers in a one-year period. METHODS: ERPs were recorded during a visual oddball task in which controls (n=15) and binge drinkers (n=15) had to detect infrequent deviant stimuli (related or unrelated to alcohol) among frequent standard stimuli. The test was performed twice with a one-year interval in order to explore the long-lasting influence of drinking habits. RESULTS: Contrary to the controls, binge drinkers showed significantly reduced amplitudes of the P1 component for both alcohol and non-alcohol-related cues and of the P3 component only for neutral cues in the second assessment compared with the first. CONCLUSION: The continuation of binge drinking over one year is associated with the development of brain functional abnormalities (indexed by the P1 component) as well as a higher reactivity to alcohol-related stimuli and/or a decreased reactivity to non-alcohol-related stimuli (indexed by the P3 component).
BACKGROUND: The continuation of binge drinking is associated with the development of neurocognitive brain abnormalities similar to those observed in patients with alcohol dependence. Alcohol cue reactivity constitutes a risk marker for alcohol dependence. Through event-related potentials (ERPs), we aimed to examine its potential presence as well as its evolution over time in binge drinkers in a one-year period. METHODS: ERPs were recorded during a visual oddball task in which controls (n=15) and binge drinkers (n=15) had to detect infrequent deviant stimuli (related or unrelated to alcohol) among frequent standard stimuli. The test was performed twice with a one-year interval in order to explore the long-lasting influence of drinking habits. RESULTS: Contrary to the controls, binge drinkers showed significantly reduced amplitudes of the P1 component for both alcohol and non-alcohol-related cues and of the P3 component only for neutral cues in the second assessment compared with the first. CONCLUSION: The continuation of binge drinking over one year is associated with the development of brain functional abnormalities (indexed by the P1 component) as well as a higher reactivity to alcohol-related stimuli and/or a decreased reactivity to non-alcohol-related stimuli (indexed by the P3 component).
Authors: Samuel F Acuff; Kathryn E Soltis; Matthew T Luciano; Lidia Z Meshesha; Paola Pedrelli; Ashley A Dennhardt; James G Murphy Journal: Psychol Addict Behav Date: 2018-10-04
Authors: Eduardo López-Caneda; Fernando Cadaveira; Angeles Correas; Alberto Crego; Fernando Maestú; Socorro Rodríguez Holguín Journal: Front Behav Neurosci Date: 2017-09-14 Impact factor: 3.558
Authors: Javier Blanco-Ramos; Fernando Cadaveira; Rocío Folgueira-Ares; Montserrat Corral; Socorro Rodríguez Holguín Journal: Int J Environ Res Public Health Date: 2019-11-18 Impact factor: 3.390