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Literature DB >> 25121740

Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?

Abstract

Dietary factors, microbial composition, and metabolism are intimately intertwined into a complex network whose activities influence important intestinal functions. In a recent issue of Cell, Belcheva et al. (2014) show that microbial-derived butyrate promotes proliferation of cancer-initiated intestinal epithelial cells, suggesting that it can act as an oncometabolite.

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Year: 2014 PMID： 25121740 PMCID： PMC4179296 DOI： 10.1016/j.chom.2014.07.011

Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023

10 in total

1. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.

Authors: Nagendra Singh; Ashish Gurav; Sathish Sivaprakasam; Evan Brady; Ravi Padia; Huidong Shi; Muthusamy Thangaraju; Puttur D Prasad; Santhakumar Manicassamy; David H Munn; Jeffrey R Lee; Stefan Offermanns; Vadivel Ganapathy
Journal: Immunity Date: 2014-01-09 Impact factor: 31.745

2. Mutator phenotype in Msh2-deficient murine embryonic fibroblasts.

Authors: A H Reitmair; R Risley; R G Bristow; T Wilson; A Ganesh; A Jang; J Peacock; S Benchimol; R P Hill; T W Mak; R Fishel; M Meuth
Journal: Cancer Res Date: 1997-09-01 Impact factor: 12.701

3. Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.

Authors: R Kongkanuntn; V J Bubb; O J Sansom; A H Wyllie; D J Harrison; A R Clarke
Journal: Oncogene Date: 1999-12-02 Impact factor: 9.867

4. Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes.

Authors: Satya Sree N Kolar; Rola Barhoumi; Evelyn S Callaway; Yang-Yi Fan; Naisyin Wang; Joanne R Lupton; Robert S Chapkin
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2007-08-23 Impact factor: 4.052

5. GPR109a: the missing link between microbiome and good health?

Authors: Christian Jobin
Journal: Immunity Date: 2014-01-16 Impact factor: 31.745

6. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation.

Authors: Dallas R Donohoe; Leonard B Collins; Aminah Wali; Rebecca Bigler; Wei Sun; Scott J Bultman
Journal: Mol Cell Date: 2012-10-11 Impact factor: 17.970

7. Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.

Authors: Antoaneta Belcheva; Thergiory Irrazabal; Susan J Robertson; Catherine Streutker; Heather Maughan; Stephen Rubino; Eduardo H Moriyama; Julia K Copeland; Anu Surendra; Sachin Kumar; Blerta Green; Kaoru Geddes; Rossanna C Pezo; William W Navarre; Michael Milosevic; Brian C Wilson; Stephen E Girardin; Thomas M S Wolever; Winfried Edelmann; David S Guttman; Dana J Philpott; Alberto Martin
Journal: Cell Date: 2014-07-17 Impact factor: 41.582

8. p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells.

Authors: S Y Archer; S Meng; A Shei; R A Hodin
Journal: Proc Natl Acad Sci U S A Date: 1998-06-09 Impact factor: 11.205

Review 9. The microbiome and cancer.

Authors: Robert F Schwabe; Christian Jobin
Journal: Nat Rev Cancer Date: 2013-10-17 Impact factor: 60.716

10. Molecular pathways: gene-environment interactions regulating dietary fiber induction of proliferation and apoptosis via butyrate for cancer prevention.

Authors: Scott J Bultman
Journal: Clin Cancer Res Date: 2013-11-22 Impact factor: 12.531

10 in total

28 in total

Review 1. Cancer and the microbiota.

Authors: Wendy S Garrett
Journal: Science Date: 2015-04-03 Impact factor: 47.728

Review 2. Microbiota modulation of myeloid cells in cancer therapy.

Authors: Romina S Goldszmid; Amiran Dzutsev; Sophie Viaud; Laurence Zitvogel; Nicholas P Restifo; Giorgio Trinchieri
Journal: Cancer Immunol Res Date: 2015-02 Impact factor: 11.151

Review 3. Molecular mechanisms of the preventable causes of cancer in the United States.

Authors: Erica A Golemis; Paul Scheet; Tim N Beck; Eward M Scolnick; David J Hunter; Ernest Hawk; Nancy Hopkins
Journal: Genes Dev Date: 2018-06-26 Impact factor: 11.361

Review 4. Crosstalk between the microbiome and epigenome: messages from bugs.

Authors: Yufeng Qin; Paul A Wade
Journal: J Biochem Date: 2018-02-01 Impact factor: 3.387

Review 5. Anticancer effects of the microbiome and its products.

Authors: Laurence Zitvogel; Romain Daillère; María Paula Roberti; Bertrand Routy; Guido Kroemer
Journal: Nat Rev Microbiol Date: 2017-05-22 Impact factor: 60.633

6. Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota.

Authors: Shu-Rong Ma; Qian Tong; Yuan Lin; Li-Bin Pan; Jie Fu; Ran Peng; Xian-Feng Zhang; Zhen-Xiong Zhao; Yang Li; Jin-Bo Yu; Lin Cong; Pei Han; Zheng-Wei Zhang; Hang Yu; Yan Wang; Jian-Dong Jiang
Journal: Signal Transduct Target Ther Date: 2022-07-07