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Literature DB >> 24439263

GPR109a: the missing link between microbiome and good health?

Abstract

A complex partnership between the host and the vast intestinal microbial ecosystem serves numerous biological activities including nutrition, immunity, and barrier function. In this issue of Immunity, Singh et al. (2014) demonstrate that microbial-derived butyrate mediated its protective activity against inflammation and colorectal cancer through GPR109a signaling.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 24439263 PMCID： PMC4337780 DOI： 10.1016/j.immuni.2013.12.009

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

11 in total

Review 1. Host-gut microbiota metabolic interactions.

Authors: Jeremy K Nicholson; Elaine Holmes; James Kinross; Remy Burcelin; Glenn Gibson; Wei Jia; Sven Pettersson
Journal: Science Date: 2012-06-06 Impact factor: 47.728

2. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.

Authors: Yukihiro Furusawa; Yuuki Obata; Shinji Fukuda; Takaho A Endo; Gaku Nakato; Daisuke Takahashi; Yumiko Nakanishi; Chikako Uetake; Keiko Kato; Tamotsu Kato; Masumi Takahashi; Noriko N Fukuda; Shinnosuke Murakami; Eiji Miyauchi; Shingo Hino; Koji Atarashi; Satoshi Onawa; Yumiko Fujimura; Trevor Lockett; Julie M Clarke; David L Topping; Masaru Tomita; Shohei Hori; Osamu Ohara; Tatsuya Morita; Haruhiko Koseki; Jun Kikuchi; Kenya Honda; Koji Hase; Hiroshi Ohno
Journal: Nature Date: 2013-11-13 Impact factor: 49.962

3. Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.

Authors: Myung H Kim; Seung G Kang; Jeong H Park; Masashi Yanagisawa; Chang H Kim
Journal: Gastroenterology Date: 2013-05-07 Impact factor: 22.682

4. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.

Authors: Nagendra Singh; Ashish Gurav; Sathish Sivaprakasam; Evan Brady; Ravi Padia; Huidong Shi; Muthusamy Thangaraju; Puttur D Prasad; Santhakumar Manicassamy; David H Munn; Jeffrey R Lee; Stefan Offermanns; Vadivel Ganapathy
Journal: Immunity Date: 2014-01-09 Impact factor: 31.745

5. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota.

Authors: June L Round; Sarkis K Mazmanian
Journal: Proc Natl Acad Sci U S A Date: 2010-06-21 Impact factor: 11.205

6. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.

Authors: Patrick M Smith; Michael R Howitt; Nicolai Panikov; Monia Michaud; Carey Ann Gallini; Mohammad Bohlooly-Y; Jonathan N Glickman; Wendy S Garrett
Journal: Science Date: 2013-07-04 Impact factor: 47.728

7. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.

Authors: Kendle M Maslowski; Angelica T Vieira; Aylwin Ng; Jan Kranich; Frederic Sierro; Di Yu; Heidi C Schilter; Michael S Rolph; Fabienne Mackay; David Artis; Ramnik J Xavier; Mauro M Teixeira; Charles R Mackay
Journal: Nature Date: 2009-10-29 Impact factor: 49.962

Review 8. The microbiome and cancer.

Authors: Robert F Schwabe; Christian Jobin
Journal: Nat Rev Cancer Date: 2013-10-17 Impact factor: 60.716

Review 9. Diet, microbiome, and the intestinal epithelium: an essential triumvirate?

Authors: Javier Rivera Guzman; Victoria Susan Conlin; Christian Jobin
Journal: Biomed Res Int Date: 2013-03-17 Impact factor: 3.411

10. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.

Authors: Nicholas Arpaia; Clarissa Campbell; Xiying Fan; Stanislav Dikiy; Joris van der Veeken; Paul deRoos; Hui Liu; Justin R Cross; Klaus Pfeffer; Paul J Coffer; Alexander Y Rudensky
Journal: Nature Date: 2013-11-13 Impact factor: 49.962

8 in total

1. Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?

Authors: Scott J Bultman; Christian Jobin
Journal: Cell Host Microbe Date: 2014-08-13 Impact factor: 21.023

Review 2. Short-Chain Fatty Acid Transporters: Role in Colonic Homeostasis.

Authors: Sathish Sivaprakasam; Yangzom D Bhutia; Shengping Yang; Vadivel Ganapathy
Journal: Compr Physiol Date: 2017-12-12 Impact factor: 9.090

Review 3. Genomic Determinants of Hypertension With a Focus on Metabolomics and the Gut Microbiome.

Authors: Panayiotis Louca; Cristina Menni; Sandosh Padmanabhan
Journal: Am J Hypertens Date: 2020-05-21 Impact factor: 2.689

4. Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches.

Authors: Sae-Hae Kim; Byeol-Hee Cho; Hiroshi Kiyono; Yong-Suk Jang
Journal: Sci Rep Date: 2017-06-21 Impact factor: 4.379

Review 5. Meat Intake and the Dose of Vitamin B₃ - Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?

Authors: Lisa J Hill; Adrian C Williams
Journal: Int J Tryptophan Res Date: 2017-05-03

GPR109a: the missing link between microbiome and good health?

Review 1. Host-gut microbiota metabolic interactions.

2. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.

3. Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.

4. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.

5. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota.

6. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.

7. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.

Review 8. The microbiome and cancer.

Review 9. Diet, microbiome, and the intestinal epithelium: an essential triumvirate?

10. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.

1. Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?

Review 2. Short-Chain Fatty Acid Transporters: Role in Colonic Homeostasis.

Review 3. Genomic Determinants of Hypertension With a Focus on Metabolomics and the Gut Microbiome.

4. Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches.

Review 5. Meat Intake and the Dose of Vitamin B₃ - Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?

Review 6. Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease.

7. G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.

Review 8. Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?

Review 1. Host-gut microbiota metabolic interactions.

Review 8. The microbiome and cancer.

Review 9. Diet, microbiome, and the intestinal epithelium: an essential triumvirate?

Review 2. Short-Chain Fatty Acid Transporters: Role in Colonic Homeostasis.

Review 3. Genomic Determinants of Hypertension With a Focus on Metabolomics and the Gut Microbiome.

Review 5. Meat Intake and the Dose of Vitamin B3 - Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?

Review 6. Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease.

Review 8. Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?

Review 5. Meat Intake and the Dose of Vitamin B₃ - Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?