Literature DB >> 25119945

Tuberculosis Control Program and patient satisfaction, Rio de Janeiro, Brazil.

Margareth Crisóstomo Portela1, Sheyla Maria Lemos Lima1, Cláudia Brito1, Vanja Maria Bessa Ferreira2, Claudia Caminha Escosteguy3, Maurício Teixeira Leite de Vasconcellos4.   

Abstract

OBJECTIVE To evaluate factors associated with users' satisfaction in the Tuberculosis Control Program. METHODS A cross-sectional study of 295 patients aged ≥ 18 years, with two or more outpatient visits in the Tuberculosis Control Program, in five cities in the metropolitan region of Rio de Janeiro, RJ, Southeastern Brazil, in 2010. Considering an estimated population of 4,345 patients, the sampling plan included 15 health care units participating in the program, divided into two strata: units in Rio de Janeiro City, selected with probability proportional to the monthly average number of outpatient visits, and units in the other four cities. In the units, four temporal clusters of five patients each were selected with equal probability, totaling 300 patients. A questionnaire investigating the users' clinical and sociodemographic variables and aspects of care and service in the program relevant to user satisfaction was applied to the patients. Descriptive statistics about users and their satisfaction with the program were obtained, and the effects of factors associated with satisfaction were estimated. RESULTS Patients were predominantly males (57.7%), with a mean age of 40.9 and with low level of schooling. The mean treatment time was 4.1 months, mostly self-administered (70.4%). Additionally, 25.8% had previously been treated for tuberculosis. There was a high level of satisfaction, especially regarding medication provision, and respect to patients by the health professionals. Patients who were younger (≤ 30), those on self-administered treatment, and with graduate level, showed less satisfaction. Suggestions to improve the services include having more doctors (70.0%), and offering exams in the same place of attendance (55.1%). CONCLUSIONS Patient satisfaction with the Tuberculosis Control Program was generally high, although lower among younger patients, those with university education and those on self-administered treatment. The study indicates the need for changes to structural and organizational aspects of care, and provides practical support for its improvement.

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Year:  2014        PMID: 25119945      PMCID: PMC4203069          DOI: 10.1590/s0034-8910.2014048004793

Source DB:  PubMed          Journal:  Rev Saude Publica        ISSN: 0034-8910            Impact factor:   2.106


INTRODUCTION

Although highly effective treatment has been available for decades and there were significant reductions in disease load between 1990 and 2010, tuberculosis (TB) remains a serious public health problem. Estimates for 2010 indicate that there are 8.5-9.2 million cases worldwide (approximately 128 cases per 100,000 inhabitants) and 1.2-1.5 million deaths (including deaths of those with an HIV co-infection), making tuberculosis the second most common cause of death from infectious disease. In the global agenda, efforts have been made and goals set for reducing the disease, a highlight being the Stop TB Strategy, consisting of six components: expanding and strengthening the directed-observed treatment strategy – DOTS); facing up to the challenges of multi-resistant tuberculosis and the TB-HIV co-infection epidemic; strengthening health care systems; commitment on the part of health care providers to controlling tuberculosis and caring for patients; increasing the empowerment of those with TB, and of the community, through partnerships; and investing in research and development of new forms of diagnosis, medicines and vaccines. Brazil currently occupies 19th place on the list of the 22 countries responsible for 81.0% of tuberculosis cases in the world and has placed the disease on its strategic agenda, with decreases recorded in incidence (from 42.8 to 36.0/100 thousand inhabitants) and mortality (from 3.1 to 2.4/100 thousand inhabitants) rates between 2001 and 2011. In 2010, Brazil detected 88.0% of estimated cases, exceeding the goal of 70.0% proposed by the World Health Organization (WHO). However, the observed cure rate, at just over 70.0%, remains well below the recommended 85.0% goal. Tuberculosis is the third most common cause of death from infectious disease, and is the most common among AIDS patients. Between 2008 and 2010, an increase was observed in multi-drug resistant tuberculosis (MDR-TB), from 365 to 605 reported cases. This situation poses a challenge in coping with the disease, as such cases often involve individuals with a history of abandoning treatment, requiring treatment for longer periods of time, using stronger drugs that have more side effects and are associated with less favorable results. In 2011, the state of Rio de Janeiro, Southeastern Brazil, had the second highest incidence and the highest mortality rate for tuberculosis in the country. There were 9,273 recorded new cases and 889 deaths, corresponding to an incidence rate of 57.6 per 100,000 inhabitants, and a mortality rate of 5.6 per 100,000 inhabitants, more than twice the national rate. Given that the rate of tuberculosis cure in Brazil remains low, patients’ adherence to treatment poses a challenge, indicating the importance of evaluating patient satisfaction regarding care received and of identifying obstacles leading to treatment being abandoned. Satisfaction is understood as the convergence between patents’ prior expectations of care and the perception of care actually received from the services, , , highlighting the following aspects: prompt care, being dealt with courteously and respectfully by health care professionals, accurate diagnosis and hope of a good prognosis, continuity and coordination of care, the absence of costs constituting a burden to the individual’s budget and, lastly, the technical quality of the medical care received. , Patients also value the physical structure and organization of the health care services, the availability of human resources and materials and, where relevant, the operation logic of the care program. , Irrespective of variation in the concepts and methods used, studies evaluating health care service user satisfaction tend to have an effect of “elevating” satisfaction rates, shown to be high, even when expectations regarding health care services are negative. If this has led, on the one hand, to the studies’ validity being questioned, on the other, it has raised speculation including, for example, access to services themselves or establishing links with health care professionals as explanatory factors of the satisfaction shown. , The elevated levels of satisfaction observed also raise questions about possible gradients in the apparent homogeneity of the evaluations. There have been several studies of tuberculosis patient satisfaction regarding treatment received, , , with descriptive national findings consistent with the observed trend of elevated satisfaction. Although these national studies suggest explanations or factors influencing user satisfaction, they are restricted to specific contexts, not based on probability samples and lacking analytical approaches capable of differentiating between levels of satisfaction. The aim of this study was to evaluate the factors associated with Tuberculosis Control Program patient satisfaction.

METHODS

A cross-sectional study was conducted on the survey population comprising patients aged ≥ 18, with at least two consultations in the Tuberculosis Control Program (TCP), and treated in the municipalities of Duque de Caxias, Nova Iguaçu, Rio de Janeiro, Sao Joao de Meriti, and Sao Gonçalo, all with high prevalence of the disease and together accounting for 86.0% of new cases of tuberculosis in the metropolitan region of Rio de Janeiro, RJ, in 2009. The survey population, accessible through the health facilities taking part in the TCP, was measured in terms of total monthly visits to the TCP in these municipalities and the number of patients was estimated at 4,345, according to a survey conducted in 2009, that allowed the selection of the sample and determination of the inclusion probabilities in the sample. Assuming one monthly consultation per patient on the TCP, estimates of consultations have been considered as a proxy of the patients treated. The survey population was divided into two geographic strata: the city of Rio de Janeiro and the remaining municipalities. As the latter stratum included only five health care units, all were included in the sample, meaning that each health clinic is a primary sampling unit. In the capital (Rio de Janeiro city) geographic stratum, the health care units were selected with probability proportional to their mean number of consultations per month and are therefore the primary sampling units. In the health care units included in the sample, temporal clusters with equal probabilities were selected. They were defined by ‘day shift of service’, if there was only one doctor on a ‘day-shift’, or by ‘day-shift-doctor’, if there was more than one doctor working the ‘day-shift’, and it was assumed that the number of patients per doctor and shift was approximately the same. Thus, the temporal clusters were the secondary sampling units in the capital geographic stratum and the primary sampling units in the other stratum. In those temporal clusters, patients were also selected with equal probability. The total sample size was calculated at 300 patients, based on the proportion maximum variance, to produce estimates with a maximum error of 5.66% for a 5% level of significance or a maximum error of 4.75% for a 10% level of significance. In order to determine the sample size of the temporal clusters and health facilities, the following parameters were fixed: (i) five patients per temporal cluster and (ii) four temporal clusters per health facility. Thus, the sample included 20 patients per health care unit and 15 units. As the second demographic stratum had five health care units included in the sample, the other 10 units were selected from the capital stratum. Five patients were systematically selected in each temporal cluster, on site, considering the list of scheduled patients and the predefined random start for each health facility and temporal cluster. Finally, the weight of the sample was calculated as the inverse of the inclusion probabilities in each stage of the sample. It is, therefore, a complex sample design with stratification and clustering, with three stages in the capital stratum (health facility, temporal cluster and patient) and two stages in the stratum of the remaining municipalities (temporal cluster and patient). The variables of selection in the stratum (capital geographic stratum or health facility in the other municipalities) and primary selection unit (health facility in the capital and the temporal cluster in the remaining municipalities) were used together with the sample weight to produce variance estimates through the primary cluster method, using the surveyfreq, surveymeans, surveyreg and surveylogistic procedures of SAS version 9.1. The final sample consisted of 295 patients, as one of the health facilities selected in the capital had only three consultation shifts per week for patients on the TCP. There was no loss in the patient selection and the few who refused were replaced by the next patient on the list of scheduled consultations in the temporal cluster selected. A semi-structured questionnaire was developed and patients interviewed individually after signing a consent form. The questionnaire investigated the clinical and sociodemographic characteristics of the patients and aspects of the TCP services related to patient satisfaction. It incorporated simple questions, extensively validated in studies of patient satisfaction and highly relevant to the context of tuberculosis treatment. At the beginning of the fieldwork, a pilot study was conducted in order to detect any problems of understanding and to make any necessary adjustments to the tool. The interviews for the questionnaires were conducted by trained researchers in the health care units where treatment took place, from February to July 2010, either before or after medical attendance. The choice of the patients to be interviewed respected the sample design. The study was approved by the Research Ethics Committee of the Escola Nacional de Saúde Pública of the Fundação Oswaldo Cruz (Protocol 125/2009) and the Rio Janeiro Municipal Health and Civil Defense Secretariat (Protocol 10/2010), on 9/12/2009 and 1/2/2010, respectively.

RESULTS

Table 1 shows the distribution of monthly tuberculosis consultations according to patients’ demographic and clinical variables. Of the total consultations, 57.7% were with males, and age varied between 18 and 78 years old, with mean of 40.9, and standard error of 0.7 years. With regards to schooling, almost 40.0% had no schooling or had not finished secondary education. Length of time being treated by the TCP at the time of the interview varied between 1.0 and 24.0 months, with a mean of 4.1 months and standard error of 0.2 months. Of the total consultations, 25.8% were with patients who had already undergone treatment for tuberculosis, of which 32.0% had not concluded the previous course of treatment. Those who reported having previously been treated for tuberculosis were then asked, using an open-ended question, the reason for abandoning treatment. The reported reasons included the belief that they had been cured before treatment finished, lack of knowledge of the severity of the disease, operational problems in remaining under treatment for a prolonged period, including difficulties accessing health care services and side effects of the drugs.
Table 1

Distribution of monthly tuberculosis consultations by sociodemographic and clinical characteristics of patients. Metropolitan Region of Rio de Janeiro, RJ, 2010. (N = 4,345)

Variablen%SE
Age (in complete years) a 40.9 (EP = 0.7); Min = 18; Max = 78
Sex
 Female1,83942.33.2
 Male2,50657.73.2
Education
 Illiterate1653.81.0
 Can read and write2375.51.8
 Elementary/secondary education incomplete1,31230.22.9
 Secondary education complete1,14426.32.0
 High school1,27429.33.7
 Undergraduate education2134.92.0
Treatment time (months)a 4.1 (EP = 0.2); Min = 1.0; Max = 24.0
Previous treatment for tuberculosis
 No3,21073.93.7
 Yes1,12025.83.7
 No information150.30.3
Completion of previous treatment (N = 1,120)
 No35932.05.4
 Yes70963.45.9
 No information524.62.7
Current type of treatment
 Self-administered3,05970.47.5
 DOTS1,28629.67.5

SE: Standard error of estimate; DOTS: Directed-observed treatment strategy

a Values expressed in average, standard error, minimum and maximum.

SE: Standard error of estimate; DOTS: Directed-observed treatment strategy a Values expressed in average, standard error, minimum and maximum. Table 2 shows perceived satisfaction of TCP users and indicates an overall high level of patient satisfaction with the aspects covered.
Table 2

Distribution of monthly consultations for tuberculosis by degree of patient satisfaction. Metropolitan Region of Rio de Janeiro, RJ, 2010. (N = 4,345)

Variablen%SE
General satisfactiona9.2 (EP = 0.2); Min = 2.0; Max = 11.0
Information and clarification about the disease and treatment during first consultation
 Excellent1,58936.63.9
 Good2,41655.64.2
 Regular2325.31.6
 Poor581.30.8
 Very poor501.20.4
Opportunity for questions/express concerns
 Excellent1,37231.63.8
 Good2,60059.83.9
 Regular2646.11.3
 Poor591.40.6
 Very poor501.10.5
Supply of medication by the clinic
 Excellent2,20850.84.3
 Good1,92944.44.3
 Regular1242.91.2
 Poor270.60.4
 Very poor481.10.7
 No information90.20.2
Form of administration of medication and their treatment
 Excellent1,51935.03.9
 Good2,40555.34.3
 Regular2255.21.4
 Poor1042.41.0
 Very poor791.80.9
 No information130.30.3
Privacy during attendance
 Excellent1,56236.04.7
 Good2,30753.15.5
 Regular2906.71.8
 Poor761.70.7
 Very poor831.90.9
 No information270.60.4
Ease of making first appointment
 Excellent1,72539.75.1
 Good1,91444.15.4
 Regular4239.73.0
 Poor1713.91.4
 Very poor1122.61.1
Waiting time for appointment
 Excellent67915.63.4
 Good1,82142.05.1
 Regular1,02323.54.3
 Poor46710.72.2
 Very poor3187.31.9
 No information370.90.6
Cleanliness of the clinic 
 Excellent54612.63.0
 Good2,21150.94.1
 Regular91721.13.1
 Poor2876.61.7
 Very poor3708.51.5
 No information140.30.3
Respect on the part of the professionals
 Excellent1,88243.34.2
 Good2,21451.04.3
 Regular1573.61.3
 Poor661.50.8
 Very poor260.60.4
Accessibility of doctor during the consultation
 Excellent1,76440.64.7
 Good2,15449.65.2
 Regular2485.71.7
 Poor862.00.7
 Very poor932.11.2
Availability of facilities to do examinations in the clinic
 Excellent78418.03.2
 Good2,24251.64.6
 Regular60514.02.5
 Poor44110.22.5
 Very poor2285.21.4
 No information451.00.5

SE: Standard error of estimate

a Values expressed in average, standard error, minimum and maximum.

SE: Standard error of estimate a Values expressed in average, standard error, minimum and maximum. Aspects of care with the highest rates of satisfaction, considering the sum of “excellent” and “good” classifications, were: provision of medicines in the unit; respect from the health care professionals; clarification regarding the disease and treatment in the first consultation; opportunity given by the professional to ask questions and clarify doubts, the method in which the treatment was administered; doctor availability during the consultation and privacy during attendance, in descending order. The rating for these aspects, summing “excellent” and “good” responses, were above 89.0%. Waiting times for a scheduled appointment, cleanliness within the unit and the possibility of diagnosis exams within the same care facility were classified as “excellent” and “good” in more than 50.0% of evaluations, but were associated with more responses indicating dissatisfaction. Table 3 shows suggestions made by patients for improving services, and are consistent with the results shown in Table 2 . Increasing the number of doctors, making appointments for consultations and conducting diagnosis exams within the same facility would make the care process quicker and more efficient, while improving the comfort and cleanliness of the units would meet expectations regarding basic health care service structures.
Table 3

Distribution of monthly consultations for tuberculosis by suggestions for improving services. Metropolitan Region of Rio de Janeiro, RJ, 2010. (N = 4,345)

Suggestion for improvement of servicesn%SE
Increased number of doctors3,04070.03.3
Increased number of nurses1,74440.15.3
Extended opening hours1,62637.45.3
Consultation by appointment2,24451.64.7
Assistance with transport1,97145.45.2
Increase in security of the clinic1,06524.54.9
Examinations in the same place as attendance2,39455.15.5
Reduction in the number of medicines89220.53.6
Improvement in the comfort of the clinic2,32853.65.8
Improvement in the cleanliness of the clinic2,26852.26.7

SE: Standard error of estimate

SE: Standard error of estimate Self-administered treatment predominated, with this being the only type of treatment on offer in six of the 15 units, and only one unit used supervised treatment (DOTS) exclusively. Overall, it was estimated that, of patients receiving tuberculosis treatment in primary health care units in the Metropolitan Region of Rio de Janeiro, 70.4% received self-administered treatment, compared with 29.6% who received DOTS. Regarding the distribution of patients according to treatment method (self-administered versus DOTS), no statistically significant differences were observed with having previously undergone tuberculosis treatment, sex or schooling. Nor did patient satisfaction differ between those on self-administered treatment and those on DOTS in relation to type of treatment specifically. Table 4 shows the bivariate analyses of the dichotomous variable differentiating more and less satisfied patients, considering nine or more and fewer than nine “excellent” and “good” responses, in the 11 items evaluated ( Table 2 ), and potential explanatory variables for its variation. Patient satisfaction was not shown to be associated with the indicator variable of previous treatment for tuberculosis or with gender. Associations with the level of satisfaction were observed for the following variables: age – less satisfaction among patients up to 30 years old; schooling – higher satisfaction among illiterate patients or those who could read and write but had no formal education and lower satisfaction among patients with undergraduate education; and treatment method – greater satisfaction among patients on DOTS.
Table 4

Bivariate analysis between satisfaction and socio-demographic and clinical characteristics. Metropolitan Region of Rio de Janeiro, RJ, 2010.

VariableMore satisfiedLess satisfiedχ2 (p)

n%SEn%SE
Received previous treatment for tuberculosis0.2739
 No2,20268.34.41,02331.74.4
 Yes85075.95.627024.15.6
Sex0.6779
 Female1,26768.94.757231.14.7
 Male1,78571.24.572128.84.5
Age (years)0.0025
 18 to 3067253.36.858946.75.8
 31 to 4060066.65.930133.45.9
 41 to 5085383.54.616916.54.6
 51 to 6062780.87.414919.27.4
 61 to 7023578.68.46421.48.4
 > 706575.820.62124.220.6
Education0.0086
 Illiterate/ Can read and write33884.18.36415.98.3
 Elementary/secondary education incomplete91269.54.140030.54.1
 Secondary education complete77667.96.936832.16.9
 High school96876.05.330624.05.3
 Undergraduate education5827.49.815572.69.8
Type of treatment0.0253
 Self-administered2,03666.64.31,02333.44.3
 Supervised treatment (DOTS)1,01679.04.627021.04.6

SE: Standard error of estimate; DOTS: Directed-observed treatment strategy

SE: Standard error of estimate; DOTS: Directed-observed treatment strategy Table 5 ratifies the results in Table 4 , indicating that the chances of patients in the age groups 31-40, 41-50, 51-60 and > 60 years being more satisfied, versus less satisfied, were, respectively, 2.3, 5.3, 4.5 and 4.1 times as much as those observed in patients aged between 18 and 30 years old. For education, it was observed that individuals who had finished high school tended to have more chance (OR = 2.1; p = 0.0853), and those with undergraduate education had less chance (OR = 0.3; p = 0.0314) of being among the more satisfied, compared to patients who had, at the most, reached the end of secondary level education. The chances of patients receiving supervised treatment being among the more satisfied were 1.9 times as much as those figures observed for patients under the self-administration method.
Table 5

Analysis of logistic regression of factors associated with higher levels of satisfaction. Metropolitan Region of Rio de Janeiro, RJ, 2010.

VariableInterceptStandard ErrorpOdds ratio
Estimate95%CI
Age (ref: 18 to 30 years)-0.330.410.4233
 31 to 40 years0.840.410.04152.331.03;5.24
 41 to 50 years1.660.460.00035.262.15;12.87
 51 to 60 years1.510.590.01054.511.42;14.31
 > 60 years1.420.650.02914.141.16;14.83
Education (ref: up to secondary level)
 High school level0.730.430.08532.080.9;4.8
 Undergraduate level-1.330.620.03140.270.08;0.89
Type of treatment (ref: self-administrated)
 Supervised - DOTS0.640.320.04401.901.02;3.55

DOTS: Directly observed treatment strategy

Concordant percentage: 68.5; c = 0.719.

DOTS: Directly observed treatment strategy Concordant percentage: 68.5; c = 0.719.

DISCUSSION

In general, the evaluation showed patient satisfaction with the TCP to be high and only a few suggestions for the improvement of care were more expressively indicated. This is consistent with the idea of an effect of ‘elevation’ of the rates of satisfaction measured, regardless of the variability of concepts and methods employed. , , , Aspects related to the interpersonal behavior dimension (respect from professionals, clarification about disease and treatment, opportunity to ask questions and remove doubts) were considered highly satisfactory , coinciding with the results of a study in a health care unit in Itaboraí, a municipality located in the metropolitan region of Rio de Janeiro, where positive assessments of the reliability, availability and guidance provided by the healthcare team were observed. However, these were also among the reasons for dropping out of treatment by some patients who had had previous treatment, exposing the existence of negative and disruptive experiences in this dimension. Lower levels of satisfaction were observed for the dimensions accessibility/convenience (waiting time for a scheduled consultation, ease of making the first appointment) physical environment (comfort and cleanliness of the facility) and availability of resources (availability of diagnosis exams in the facility). Dissatisfaction with the unavailability of exams coincides to some extent with findings presented by Palha et al, and is a problem that needs to be addressed within the context of tuberculosis care, irrespective of whether based on the Family Health Program or reference outpatient unities. , Access to treatment is an attribute that is highly valued by public health service users, who, particularly in situations of socioeconomic vulnerability, have no other health care alternatives. There was no association between satisfaction level and previous treatment for tuberculosis, treatment duration or gender, unlike a study conducted in Uganda that found that patients undergoing treatment for longer periods and women were more satisfied with the program. It was observed that younger and more educated patients reported lower satisfaction levels, which may be related to higher standards of expectations, and, surprisingly, patients with high school reported higher satisfaction levels than those that had, at the most, reached the end of secondary education. Overall satisfaction was higher among patients under DOTS, suggesting greater adherence to the program with this type of treatment. This may also indicate that other organizational aspects related to the provision of DOTS have a positive effect on satisfaction. This finding is consistent with other studies linking the use of DOTS to other strategies that improve the structure and process of tuberculosis care, as well as to better results, , reinforcing the importance of expanding this and other internationally recommended strategies for tuberculosis treatment. Some methodological aspects may have influenced the findings of this study. Low adherence to the suggestion of ‘less medicine’ could have resulted from the fear of not receiving all the medication necessary for the treatment due to economizing on resource. Besides this, the low valorization of subsidized transport could be attributed to the low number of patients undergoing the DOTS treatment method, which requires the patient to go to the health care unit to take his or her medicine. Patients undergoing retreatment, about a quarter of the interviewees, claimed that they abandoned the program as they believed they were cured before the treatment had been completed, because of a lack of knowledge of the severity of the disease and due to operational difficulties for maintaining treatment for long periods, including difficulties in accessing the health services and the side effects of the medication. These results are similar to those found in a study of Kaona et al, conducted in Ndola, Zambia, which identified factors contributing to tuberculosis patients’ non-adherence to treatment, based on a household survey conducted in six randomly selected areas, including 400 recruited patients and 726 patients who had been in treatment for the last six months. The results presented here for the metropolitan region of Rio de Janeiro confirm a trend of higher incidence of tuberculosis among relatively young men (average age approximately 41 years old) and with low level of education, in accordance with other studies conducted in Brazilian municipalities. , More than 70.0% of treatments were self-administered, which is inconsistent with the recommendations for treating tuberculosis. The DOTS strategy is recommended as the main strategy for treatment, especially in cases of retreatment, corresponding to slightly more than 25.0% of the patients in this study. This result is a counterpoint to the study by Palha et al, in which patients were predominantly under supervised treatment, although some adjustments to contextual specificities of the patients are needed, such as considering the cost of transportation, the relevance of the proximity of the service and the journey time. Finally, the difficulty in identifying studies able to offer benchmarks compatible to our findings should be highlighted, suggesting the need for further studies on patient satisfaction with tuberculosis care in less specific contexts and based on more rigorous scientific methods. Studies of patient satisfaction within public services can bring to light users’ needs, perceptions and expectations, although health services had long remained distant from the possibility of review by users, alleging that they would be devoid of technical knowledge, and therefore unprepared for evaluation. From the present study we captured the need for improvements in the structure of health services (cleanliness, comfort, availability to complete examinations in the facility and having more doctors) and in the organization of care (reduction in waiting times for scheduled consultations), which also constitutes a practical finding for improving the TCP, aimed at increasing its effectiveness.
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Review 6.  User-experience and patient satisfaction with quality of tuberculosis care in India: A mixed-methods literature review.

Authors:  Himani Bhatnagar
Journal:  J Clin Tuberc Other Mycobact Dis       Date:  2019-10-25
  6 in total

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