Literature DB >> 2511973

Diagnosis and treatment of cervical intraepithelial neoplasia in general practice.

D B Johnson1, C J Rowlands.   

Abstract

OBJECTIVE: To audit the first five years of a colposcopy and treatment service for cervical dysplasia established within a general practice.
DESIGN: A cervical smear register was established to determine which women were "at risk" of dysplasia. The results of colposcopy and treatment of dysplasia were analysed.
SETTING: A large rural general practice with community hospital facilities in mid-Wales. PATIENTS: 4437 Women at risk in a total practice population of 14,100.
INTERVENTIONS: Colposcopy of women with dyskaryotic smear results, persistent inflammatory smear results, or vulval warts. Treatment of women with proved dysplasia by electrodiathermy of the cervix or cone biopsy.
RESULTS: 138 Women with dysplasia were diagnosed over five years: 36 mild, 97 moderate or severe, and five with microinvasion. Despite a 78% smear rate of at risk women over five years, nine invasive cancers still occurred.
CONCLUSIONS: The results of treatment are acceptable. Cervical dysplasia has become very common, the risk of a dysplasia in women aged 20-39 who had smear tests being one in 14 over five years.

Entities:  

Mesh:

Year:  1989        PMID: 2511973      PMCID: PMC1837948          DOI: 10.1136/bmj.299.6707.1083

Source DB:  PubMed          Journal:  BMJ        ISSN: 0959-8138


  13 in total

1.  Oral contraceptive use and malignancies of the genital tract. Results from the Royal College of General Practitioners' Oral Contraception Study.

Authors:  V Beral; P Hannaford; C Kay
Journal:  Lancet       Date:  1988-12-10       Impact factor: 79.321

2.  Colposcopy: who, when, where and by whom?

Authors:  P Walker; A Singer
Journal:  Br J Obstet Gynaecol       Date:  1987-11

3.  Cervical smears: choice of spatula is critical.

Authors:  W K Blenkinsopp; J L Jenkins
Journal:  Lancet       Date:  1986-10-25       Impact factor: 79.321

4.  Does mild atypia on a cervical smear warrant further investigation?

Authors:  E M Walker; J Dodgson; I D Duncan
Journal:  Lancet       Date:  1986-09-20       Impact factor: 79.321

5.  Improving the effectiveness of cervical cancer screening.

Authors:  R Ellman; J Chamberlain
Journal:  J R Coll Gen Pract       Date:  1984-10

6.  Colposcopy in a family planning clinic: a future model?

Authors:  H C Kitchener; R A Burnett; E S Wilson; J W Cordiner
Journal:  Br Med J (Clin Res Ed)       Date:  1987-05-23

7.  Effects of Monsel's solution in uterine cervix.

Authors:  J R Davis; K K Steinbronn; A R Graham; B V Dawson
Journal:  Am J Clin Pathol       Date:  1984-09       Impact factor: 2.493

8.  Quinquennial cervical smears: every woman's right and every general practitioner's responsibility.

Authors:  P Standing; S Mercer
Journal:  Br Med J (Clin Res Ed)       Date:  1984-10-06

9.  Neoplasia of the cervix uteri and contraception: a possible adverse effect of the pill.

Authors:  M P Vessey; M Lawless; K McPherson; D Yeates
Journal:  Lancet       Date:  1983-10-22       Impact factor: 79.321

10.  Treatment of cervical intraepithelial neoplasia (CIN) by radical electrocoagulation diathermy: 5 years' experience.

Authors:  J A Giles; P G Walker; P A Chalk
Journal:  Br J Obstet Gynaecol       Date:  1987-11
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  4 in total

1.  A comparison of four cytological sampling techniques in a genitourinary medicine clinic.

Authors:  A Szarewski; J Cuzick; M Nayagam; R N Thin
Journal:  Genitourin Med       Date:  1990-12

2.  Cervical intraepithelial neoplasia in general practice.

Authors:  K Boomla; J Robson; S Fitzpatrick
Journal:  BMJ       Date:  1989-11-25

3.  Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia.

Authors:  S K Jonas; C Benedetto; A Flatman; R H Hammond; L Micheletti; C Riley; P A Riley; D J Spargo; M Zonca; T F Slater
Journal:  Br J Cancer       Date:  1992-07       Impact factor: 7.640

4.  Five-Class Classification of Cervical Pap Smear Images: A Study of CNN-Error-Correcting SVM Models.

Authors:  Audrey K C Huong; Kim Gaik Tay; Xavier T I Ngu
Journal:  Healthc Inform Res       Date:  2021-10-31
  4 in total

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