| Literature DB >> 25111592 |
Kien Voon Kong1, Weng Kee Leong, Zhiyong Lam, Tianxun Gong, Douglas Goh, Weber Kam On Lau, Malini Olivo.
Abstract
A metal carbonyl-functionalized nanostructured substrate can be used in a rapid and simple assay for the detection of A1AT, a potential biomarker for bladder cancer, in clinical urine samples. The assay involves monitoring changes in the carbonyl stretching vibrations of the metal carbonyl via surface-enhanced Raman spectroscopy (SERS). These vibrations lie in the absorption spectral window of 1800-2200 cm(-1), which is free of any spectral interference from biomolecules.Entities:
Keywords: A1AT; SERS; bioassays; biomarkers; functionalized substrates; osmium carbonyl clusters; urine
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Year: 2014 PMID： 25111592 DOI： 10.1002/smll.201401713
Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281