Sunil Kukreja1, Sudheer Ambekar1, Mayur Sharma1, Anthony Hunkyun Sin1, Anil Nanda2. 1. Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA. 2. Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA. Electronic address: ananda@lsuhsc.edu.
Abstract
OBJECTIVES: The results in earlier studies have described a variable association with age, extent of resection, and radiotherapy (RT) correlating with the survival of myxopapillary ependymomas. The aim of our study is to perform a survival analysis on patient data gathered from a comprehensive review of the literature and determine the influence of these factors on progression-free (PFS) and overall survival (OS). METHODS: A PubMed search was performed to select the articles containing information about the critical events (recurrence/death), time to events, and treatment characteristics (extent of resection with or without RT) in the patients with spinal myxopapillary ependymomas. RESULTS: A total of 337 patients with information regarding the critical events, time to events, and treatment characteristics was selected for the inclusion. Patients in gross-total resection group had better PFS and OS (P = 0.001, P = 0.000 respectively). The patients in older age group (>35 years) had better PFS (P = 0.008). Overall PFS did not improve if RT was combined with surgery compared with surgery alone; however, the adjuvant RT benefitted the patients age ≤35 years. RT dose >50 Gy had significant influence on the PFS (P = 0.034). CONCLUSION: Gross-total resection plays the most important role in improving PFS and OS. Older patients had better PFS; however, the influence of adjuvant RT was significant in younger age groups. A dose of >50 Gy improves the results, but a randomized controlled study is warranted to arrive at a definite conclusion.
OBJECTIVES: The results in earlier studies have described a variable association with age, extent of resection, and radiotherapy (RT) correlating with the survival of myxopapillary ependymomas. The aim of our study is to perform a survival analysis on patient data gathered from a comprehensive review of the literature and determine the influence of these factors on progression-free (PFS) and overall survival (OS). METHODS: A PubMed search was performed to select the articles containing information about the critical events (recurrence/death), time to events, and treatment characteristics (extent of resection with or without RT) in the patients with spinal myxopapillary ependymomas. RESULTS: A total of 337 patients with information regarding the critical events, time to events, and treatment characteristics was selected for the inclusion. Patients in gross-total resection group had better PFS and OS (P = 0.001, P = 0.000 respectively). The patients in older age group (>35 years) had better PFS (P = 0.008). Overall PFS did not improve if RT was combined with surgery compared with surgery alone; however, the adjuvant RT benefitted the patients age ≤35 years. RT dose >50 Gy had significant influence on the PFS (P = 0.034). CONCLUSION: Gross-total resection plays the most important role in improving PFS and OS. Older patients had better PFS; however, the influence of adjuvant RT was significant in younger age groups. A dose of >50 Gy improves the results, but a randomized controlled study is warranted to arrive at a definite conclusion.
Authors: Michael Bockmayr; Kim Harnisch; Lara C Pohl; Leonille Schweizer; Theresa Mohme; Meik Körner; Malik Alawi; Abigail K Suwala; Mario M Dorostkar; Camelia M Monoranu; Martin Hasselblatt; Annika K Wefers; David Capper; Jürgen Hench; Stephan Frank; Timothy E Richardson; Ivy Tran; Elisa Liu; Matija Snuderl; Lara Engertsberger; Martin Benesch; Andreas von Deimling; Denise Obrecht; Martin Mynarek; Stefan Rutkowski; Markus Glatzel; Julia E Neumann; Ulrich Schüller Journal: Neuro Oncol Date: 2022-10-03 Impact factor: 13.029
Authors: Zhenxing Sun; Dan Yuan; Yaxing Sun; Yi Guo; Guoqin Wang; Peihai Zhang; James Wang; Wei Shi; Guihuai Wang Journal: J Int Med Res Date: 2022-03 Impact factor: 1.671