| Literature DB >> 25106608 |
Md Kabir Uddin Sikder1, Kyle A Stone1, P B Sunil Kumar2, Mohamed Laradji3.
Abstract
We investigate the combined effects of transmembrane proteins and the subjacent cytoskeleton on the dynamics of phase separation in multicomponent lipid bilayers using computer simulations of a particle-based implicit solvent model for lipid membranes with soft-core interactions. We find that microphase separation can be achieved by the protein confinement by the cytoskeleton. Our results have relevance to the finite size of lipid rafts in the plasma membrane of mammalian cells.Entities:
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Year: 2014 PMID： 25106608 PMCID： PMC4119197 DOI： 10.1063/1.4890655
Source DB: PubMed Journal: J Chem Phys ISSN： 0021-9606 Impact factor: 3.488