| Literature DB >> 25104210 |
Silvio Antoniak, Erica Sparkenbaugh, Rafal Pawlinski1.
Abstract
Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.Entities:
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Year: 2014 PMID: 25104210 PMCID: PMC4382753 DOI: 10.1160/TH14-03-0243
Source DB: PubMed Journal: Thromb Haemost ISSN: 0340-6245 Impact factor: 5.249