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Literature DB >> 25102091

Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

Ujjwal Neogi¹, Shwetha D Rao, Irene Bontell, Jens Verheyen, Vasudev R Rao, Sagar C Gore, Neelesh Soni, Anita Shet, Eugen Schülter, Maria L Ekstrand, Amogne Wondwossen, Rolf Kaiser, Mallur S Madhusudhan, Vinayaka R Prasad, Anders Sonnerborg.

Abstract

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.

Entities: Chemical Disease Gene Mutation Species

Mesh：

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Year: 2014 PMID： 25102091 PMCID： PMC4198440 DOI： 10.1097/QAD.0000000000000419

Source DB: PubMed Journal: AIDS ISSN： 0269-9370 Impact factor: 4.177

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