Talia R Weiss Wiesel1, Christian J Nelson2, William P Tew3, Molly Hardt4, Supriya Gupta Mohile5, Cynthia Owusu6, Heidi D Klepin7, Cary P Gross8, Ajeet Gajra9, Stuart M Lichtman10, Rupal Ramani4, Vani Katheria4, Laura Zavala4, Arti Hurria4. 1. Payne Whitney Manhattan, NewYork-Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA. 2. Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3. Memorial Sloan Kettering Cancer Center, Gynecologic Medical Oncology Service, New York, NY, USA. 4. City of Hope Comprehensive Cancer Center, Duarte, CA, USA. 5. University of Rochester James P. Wilmot Cancer Center, Rochester, NY, USA. 6. Case Western Reserve University School of Medicine and Case Comprehensive Cancer Center, Cleveland, OH, USA. 7. Wake Forest School of Medicine, Winston-Salem, NC, USA. 8. Cancer Outcomes Public Policy and Effectiveness Research (COPPER) Center, Yale University School of Medicine, New Haven, CT, USA. 9. Upstate Medical University and VA Medical Center, Syracuse, NY, USA. 10. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Abstract
OBJECTIVE: In older men with prostate cancer, aging is associated with reduced anxiety and increased depression. The purpose of this study was to examine the association among age, anxiety, and depression in a cohort of older adults receiving chemotherapy. METHODS: This is a secondary analysis of a prospective longitudinal study investigating chemotherapy toxicity in older adults with cancer. Baseline data (pre-chemotherapy) included: age, sociodemographics, tumor and treatment factors, functional status, comorbidities, psychological state (measured by the Hospital Anxiety and Depression Scale), and social support. Univariate and multiple regression analyses were conducted to test the relationship between age, anxiety, and depression. RESULTS: The average age of the 500 patients (56% females) was 73.1. The majority had late stage disease: 22% Stage III and 61% stage IV. Clinically significant depression was reported in 12.6%. Clinically significant anxiety was reported in 20.9%. In univariate analyses, there was no association between anxiety and age, or depression and age. In multivariable analyses, older age (p=0.05) was associated with decreased anxiety, as well as lack of social support (p<0.01) and increased number of comorbidities (p<0.01). In multivariable analysis, depression was associated with lack of social support (p<0.01), increased number of comorbidities (p<0.01), and advanced stage (p<0.01). CONCLUSIONS: This study supports previous research that anxiety decreases with age in older adults with cancer. However, depression remained constant with increasing age. Greater resources and attention to identifying and treating the psychological sequelae of cancer in older adults are warranted.
OBJECTIVE: In older men with prostate cancer, aging is associated with reduced anxiety and increased depression. The purpose of this study was to examine the association among age, anxiety, and depression in a cohort of older adults receiving chemotherapy. METHODS: This is a secondary analysis of a prospective longitudinal study investigating chemotherapy toxicity in older adults with cancer. Baseline data (pre-chemotherapy) included: age, sociodemographics, tumor and treatment factors, functional status, comorbidities, psychological state (measured by the Hospital Anxiety and Depression Scale), and social support. Univariate and multiple regression analyses were conducted to test the relationship between age, anxiety, and depression. RESULTS: The average age of the 500 patients (56% females) was 73.1. The majority had late stage disease: 22% Stage III and 61% stage IV. Clinically significant depression was reported in 12.6%. Clinically significant anxiety was reported in 20.9%. In univariate analyses, there was no association between anxiety and age, or depression and age. In multivariable analyses, older age (p=0.05) was associated with decreased anxiety, as well as lack of social support (p<0.01) and increased number of comorbidities (p<0.01). In multivariable analysis, depression was associated with lack of social support (p<0.01), increased number of comorbidities (p<0.01), and advanced stage (p<0.01). CONCLUSIONS: This study supports previous research that anxiety decreases with age in older adults with cancer. However, depression remained constant with increasing age. Greater resources and attention to identifying and treating the psychological sequelae of cancer in older adults are warranted.
Authors: Grant R Williams; Kathryn E Weaver; Glenn J Lesser; Emily Dressler; Karen M Winkfield; Heather B Neuman; Anne E Kazak; Ruth Carlos; Lucy J Gansauer; Charles S Kamen; Joseph M Unger; Supriya G Mohile; Heidi D Klepin Journal: Oncologist Date: 2020-08-31
Authors: Mackenzi Pergolotti; Allison M Deal; Grant R Williams; Ashley L Bryant; Lauren McCarthy; Kirsten A Nyrop; Kelley R Covington; Bryce B Reeve; Ethan Basch; Hyman B Muss Journal: J Am Geriatr Soc Date: 2019-05 Impact factor: 5.562
Authors: Abigail S Robbertz; David M Weiss; Farrukh T Awan; John C Byrd; Kerry A Rogers; Jennifer A Woyach Journal: Support Care Cancer Date: 2019-07-22 Impact factor: 3.603
Authors: Nikesha Gilmore; Lee Kehoe; Jessica Bauer; Huiwen Xu; Bianca Hall; Megan Wells; Lianlian Lei; Eva Culakova; Marie Flannery; Valerie Aarne Grossman; Ronak Amir Sardari; Himal Subramanya; Sindhuja Kadambi; Elizabeth Belcher; Jared Kettinger; Mark A O'Rourke; Elie G Dib; Nicholas J Vogelzang; William Dale; Supriya Mohile Journal: Oncologist Date: 2021-09-19
Authors: Mackenzi Pergolotti; Michelle M Langer; Allison M Deal; Hyman B Muss; Kirsten Nyrop; Grant Williams Journal: J Geriatr Oncol Date: 2018-09-08 Impact factor: 3.599