S Fadda1, H Nassar, S M Gamal, H Al-azizi. 1. Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Egypt-Cairo-Nasr city- emtedad ramsis street-4 elgabal elakhdar building, Cairo , Egypt.
Abstract
AIM OF THE WORK: To detect the incidence of premature atherosclerosis in systemic lupus erythematosus (SLE) patients and to study its association with disease activity and damage indices. PATIENTS AND METHODS: This study involved 50 adult female SLE patients with mean age 26.24 ± 8.63 years and mean disease duration 3.44 ± 4.01 years. The control group comprised 25 healthy adult females. All patients were subjected to a detailed clinical examination and laboratory investigations, and full case history was recorded. Assessment of disease activity was performed according to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and disease damage was assessed using the Systemic Lupus International Collaborating Clinics (SLICC) score. B mode ultrasound was used to measure the intima-media wall thickness (IMT) and detect the presence of carotid plaques. RESULTS: In 15 patients (30 %), positive ultrasonographic findings represented by a significant increase in IMT (> 0.9 mm) could be shown; plaques were found in 3 of these patients (6 %). A significant difference was found between SLE patients and controls in terms of IMT (P < 0.0001). On subgrouping the SLE patients according to their IMT, there was a significant difference between those with thickened and normal IMT in terms of SLEDAI (P < 0.0001) and SLICC (p = 0.035) scores. CONCLUSION: Subclinical atherosclerosis is frequent in SLE patients. Increased disease activity and damage are associated with the occurrence of premature atherosclerosis.
AIM OF THE WORK: To detect the incidence of premature atherosclerosis in systemic lupus erythematosus (SLE) patients and to study its association with disease activity and damage indices. PATIENTS AND METHODS: This study involved 50 adult female SLEpatients with mean age 26.24 ± 8.63 years and mean disease duration 3.44 ± 4.01 years. The control group comprised 25 healthy adult females. All patients were subjected to a detailed clinical examination and laboratory investigations, and full case history was recorded. Assessment of disease activity was performed according to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and disease damage was assessed using the Systemic Lupus International Collaborating Clinics (SLICC) score. B mode ultrasound was used to measure the intima-media wall thickness (IMT) and detect the presence of carotid plaques. RESULTS: In 15 patients (30 %), positive ultrasonographic findings represented by a significant increase in IMT (> 0.9 mm) could be shown; plaques were found in 3 of these patients (6 %). A significant difference was found between SLEpatients and controls in terms of IMT (P < 0.0001). On subgrouping the SLEpatients according to their IMT, there was a significant difference between those with thickened and normal IMT in terms of SLEDAI (P < 0.0001) and SLICC (p = 0.035) scores. CONCLUSION: Subclinical atherosclerosis is frequent in SLEpatients. Increased disease activity and damage are associated with the occurrence of premature atherosclerosis.
Authors: Alfonso Corrales; José A Parra; Carlos González-Juanatey; Javier Rueda-Gotor; Ricardo Blanco; Javier Llorca; Miguel A González-Gay Journal: Ann Rheum Dis Date: 2013-07-13 Impact factor: 19.103
Authors: Mary J Roman; Beth-Ann Shanker; Adrienne Davis; Michael D Lockshin; Lisa Sammaritano; Ronit Simantov; Mary K Crow; Joseph E Schwartz; Stephen A Paget; Richard B Devereux; Jane E Salmon Journal: N Engl J Med Date: 2003-12-18 Impact factor: 91.245
Authors: D Gladman; E Ginzler; C Goldsmith; P Fortin; M Liang; M Urowitz; P Bacon; S Bombardieri; J Hanly; E Hay; D Isenberg; J Jones; K Kalunian; P Maddison; O Nived; M Petri; M Richter; J Sanchez-Guerrero; M Snaith; G Sturfelt; D Symmons; A Zoma Journal: Arthritis Rheum Date: 1996-03
Authors: E Ammirati; E P Bozzolo; R Contri; A Baragetti; A G Palini; D Cianflone; M Banfi; P Uboldi; G Bottoni; I Scotti; A Pirillo; L Grigore; K Garlaschelli; C Monaco; A L Catapano; M G Sabbadini; A A Manfredi; G D Norata Journal: Nutr Metab Cardiovasc Dis Date: 2014-02-01 Impact factor: 4.222
Authors: Mónica Vázquez-Del Mercado; Felipe de J Perez-Vazquez; Eduardo Gomez-Bañuelos; Efrain Chavarria-Avila; Arcelia Llamas-García; Karla I Arrona-Rios; Gustavo Ignacio Diaz-Rubio; Sergio Durán-Barragán; Rosa E Navarro-Hernández; Bethel P Jordán-Estrada; Natalia Prado-Bachega; Miguel A A Gonzalez-Beltran; Carlos Ramos-Becerra; Fernando Grover-Paez; David Cardona-Müller; Ernesto G Cardona-Muñoz Journal: PLoS One Date: 2018-12-05 Impact factor: 3.240