Jian Xu1, Hongliang Zhao1, Xiaoying Wang2, Yuxiang Bai3, Liwen Liu4, Ying Liu1, Mengqi Wei1, Jian Li1, Minwen Zheng5. 1. Department of Radiology, Xijing Hospital, Fourth Military Medical University, 127# West Changle Rd, Xi'an 710032, Shaanxi Province, P.R. China. 2. Department of Ultrasound, The People's Liberation Army No. 323 Hospital, Xi'an, Shaanxi Province, P.R. China. 3. Department of Health Statistics, Fourth Military Medical University, Xi'an, Shaanxi province, P.R. China. 4. Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi province, P.R. China. 5. Department of Radiology, Xijing Hospital, Fourth Military Medical University, 127# West Changle Rd, Xi'an 710032, Shaanxi Province, P.R. China. Electronic address: zhengmw2007@163.com.
Abstract
RATIONALE AND OBJECTIVES: To evaluate the diagnostic accuracy, image quality, and radiation dose of prospective electrocardiogram (ECG)-triggered high-pitch dual-source computed tomography (DSCT) in infants and young children with complex coarctation of the aorta (CoA). MATERIALS AND METHODS: Forty pediatric patients aged < 4 years with suspected CoA underwent prospective ECG-triggered high-pitch DSCT angiography and transthoracic echocardiography (TTE). Surgery and/or conventional cardiac angiography (CCA) were performed in all patients. The diagnostic accuracy of DSCT angiography and TTE was compared to the surgical and/or CCA findings. The causes of misdiagnosis and miss were analyzed, and the advantages and limitation of both imaging modalities were evaluated. Image quality of DSCT was evaluated, and effective radiation dose was calculated. RESULTS: The sensitivity, specificity, positive predictive value, negative predictive value, and overall diagnostic accuracy of DSCT in evaluation of complex CoA were 92.37%, 98.51%, 97.32%, 93.57%, and 96.25%, respectively. There was a significant difference in the accuracy between DSCT and TTE (χ² = 9.9, P＜.05). For a total of 80 extracardiac anomalies, the sensitivity (98.8%, 79/80) of DSCT was greater than that of TTE (62.5%; 50 of 80). On the contrary, for 38 cardiac anomalies, the sensitivity (78.9%, 30 of 38) of DSCT was lesser than that of TTE (100%; 38 of 38). The mean score of image quality was 4.27 ± 0.73. The mean effective radiation dose was 0.20 ± 0.09 mSv. CONCLUSIONS: Prospective ECG-triggered high-pitch DSCT may be a clinical feasible modality in the evaluation of pediatric patients with complex CoA, providing adequate image quality, high diagnostic accuracy, and low radiation dose.
RATIONALE AND OBJECTIVES: To evaluate the diagnostic accuracy, image quality, and radiation dose of prospective electrocardiogram (ECG)-triggered high-pitch dual-source computed tomography (DSCT) in infants and young children with complex coarctation of the aorta (CoA). MATERIALS AND METHODS: Forty pediatric patients aged < 4 years with suspected CoA underwent prospective ECG-triggered high-pitch DSCT angiography and transthoracic echocardiography (TTE). Surgery and/or conventional cardiac angiography (CCA) were performed in all patients. The diagnostic accuracy of DSCT angiography and TTE was compared to the surgical and/or CCA findings. The causes of misdiagnosis and miss were analyzed, and the advantages and limitation of both imaging modalities were evaluated. Image quality of DSCT was evaluated, and effective radiation dose was calculated. RESULTS: The sensitivity, specificity, positive predictive value, negative predictive value, and overall diagnostic accuracy of DSCT in evaluation of complex CoA were 92.37%, 98.51%, 97.32%, 93.57%, and 96.25%, respectively. There was a significant difference in the accuracy between DSCT and TTE (χ² = 9.9, P＜.05). For a total of 80 extracardiac anomalies, the sensitivity (98.8%, 79/80) of DSCT was greater than that of TTE (62.5%; 50 of 80). On the contrary, for 38 cardiac anomalies, the sensitivity (78.9%, 30 of 38) of DSCT was lesser than that of TTE (100%; 38 of 38). The mean score of image quality was 4.27 ± 0.73. The mean effective radiation dose was 0.20 ± 0.09 mSv. CONCLUSIONS: Prospective ECG-triggered high-pitch DSCT may be a clinical feasible modality in the evaluation of pediatric patients with complex CoA, providing adequate image quality, high diagnostic accuracy, and low radiation dose.
Authors: Xian-Feng Chen; Fan Jiang; Lin Li; Yan Chen; Xin Chen; Yan-Yan Jiang; Li Xiang; Xiao-Jing Ma Journal: Exp Ther Med Date: 2017-06-13 Impact factor: 2.447
Authors: Andrew G Sherrah; Stuart M Grieve; Richmond W Jeremy; Paul G Bannon; Michael P Vallely; Rajesh Puranik Journal: Front Cardiovasc Med Date: 2015-02-19