| Literature DB >> 25092583 |
V Karthick1, V Ganesh Kumar2, T Stalin Dhas1, G Singaravelu3, A Mohamed Sadiq4, K Govindaraju1.
Abstract
Development of novel antidiabetic agents using various organic compounds and biomolecules has been in practice for a long time. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties such as small size, biocompatibility and ability to penetrate cell membrane for carrying drugs. Herein, in vivo antidiabetic activity of gold nanoparticles (AuNPs) synthesized using the antidiabetic potent plant Gymnema sylvestre R. Br on wistar albino rats has been evaluated. The formation of AuNPs and their morphology were confirmed using spectroscopic and microscopic analyses, respectively. The treatment of AuNPs has shown significant reduction in blood glucose level on diabetic rats. AuNPs were also tested for its anti-inflammatory effect by estimating the serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and high-sensitive C-reactive protein (CRP).Entities:
Keywords: Diabetes; Electron microscopy; Gold nanoparticles; Gymnema sylvestre; Hypoglycemia
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Year: 2014 PMID： 25092583 DOI： 10.1016/j.colsurfb.2014.07.022
Source DB: PubMed Journal: Colloids Surf B Biointerfaces ISSN： 0927-7765 Impact factor: 5.268