| Literature DB >> 25092406 |
Audrey E Mayfield1, Everad L Tilokee1, Darryl R Davis2.
Abstract
Despite advances in treatment, heart failure remains one of the top killers in Canada. This recognition motivated a new research focus to harness the fundamental repair properties of the human heart. Since then, cardiac stem cells (CSCs) have emerged as a promising cell candidate to regenerate damaged hearts. The rationale of this approach is simple with ex vivo amplification of CSCs from clinical-grade biopsies, followed by delivery to areas of injury, where they engraft and regenerate the heart. In this review we will summarize recent advances and discuss future developments in CSC-mediated cardiac repair to treat the growing number of Canadians living with and dying from heart failure.Entities:
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Year: 2014 PMID: 25092406 DOI: 10.1016/j.cjca.2014.03.018
Source DB: PubMed Journal: Can J Cardiol ISSN: 0828-282X Impact factor: 5.223