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Literature DB >> 25087188

TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways.

Christopher P Wardlaw¹, Antony M Carr², Antony W Oliver³.

Abstract

Human TopBP1 contains nine BRCT domains and functions in DNA replication initiation, checkpoint signalling, DNA repair and influences transcriptional control. TopBP1 and its homologues have been the subject of numerous scientific publications since the last comprehensive review in 2005, emerging as a key scaffold protein that links crucial components within these distinct cellular processes. This review focuses on recently published work, with particular emphasis on structural insights into TopBP1 function and the binding partners identified for DNA replication initiation, DNA-dependent checkpoints, DNA repair and transcription. We further summarise what is known about TopBP1 and links to human disease.

Entities: Chemical

Keywords: Scaffold proteins; TopBP1 functions in checkpoint signalling; TopBP1 functions in replication; TopBP1 review

Mesh：

Substances：

Year: 2014 PMID： 25087188 DOI： 10.1016/j.dnarep.2014.06.004

Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856

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Cited

53 in total

1. TopBP1-mediated DNA processing during mitosis.

Authors: Irene Gallina; Signe Korbo Christiansen; Rune Troelsgaard Pedersen; Michael Lisby; Vibe H Oestergaard
Journal: Cell Cycle Date: 2016 Impact factor: 4.534

Review 2. DNA Repair in Drosophila: Mutagens, Models, and Missing Genes.

Authors: Jeff Sekelsky
Journal: Genetics Date: 2017-02 Impact factor: 4.562

3. Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions.

Authors: José R Cussiol; Carolyn M Jablonowski; Askar Yimit; Grant W Brown; Marcus B Smolka
Journal: EMBO J Date: 2015-04-20 Impact factor: 11.598

4. The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosis.

Authors: Lissa N Princz; Dalia Gritenaite; Boris Pfander
Journal: Cell Cycle Date: 2015 Impact factor: 4.534

5. RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in Xenopus egg extracts.

Authors: Yosuke Sanuki; Yumiko Kubota; Masato T Kanemaki; Tatsuro S Takahashi; Satoru Mimura; Haruhiko Takisawa
Journal: Cell Cycle Date: 2015 Impact factor: 4.534

6. Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage.

Authors: Julyana Acevedo; Shan Yan; W Matthew Michael
Journal: J Biol Chem Date: 2016-04-26 Impact factor: 5.157

TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways.

1. TopBP1-mediated DNA processing during mitosis.

Review 2. DNA Repair in Drosophila: Mutagens, Models, and Missing Genes.

3. Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions.

4. The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosis.

5. RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in Xenopus egg extracts.

6. Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage.

Review 7. The Rtt107 BRCT scaffold and its partner modification enzymes collaborate to promote replication.

Review 8. Multi-BRCT scaffolds use distinct strategies to support genome maintenance.

9. Structural Insight into BLM Recognition by TopBP1.

10. Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.