Literature DB >> 2508273

Botulinum C2 toxin treatment increases the G-actin pool in intact chicken cells: a model for the cytopathic action of actin-ADP-ribosylating toxins.

K Aktories1, K H Reuner, P Presek, M Bärmann.   

Abstract

Botulinum C2 toxin ADP-ribosylates actin in intact chicken embryo cells in a concentration-dependent manner. This effect correlates with an enhancement in the inhibitory potency of the respective cell lysates on DNAse I activity, indicating an increase in the cellular G-actin content of toxin-treated cells. The data support our view, that ADP-ribosylation of cellular actin with subsequent depolymerization of cytoskeleton-associated F-actin to monomeric G-actin is involved in the cytotoxic effects of botulinum C2 toxin. A model of the cytopathic action of actin-ADP-ribosylating toxins is presented.

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Year:  1989        PMID： 2508273     DOI： 10.1016/0041-0101(89)90149-9

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  9 in total

1.  Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro.

Authors:  N Suttorp; M Polley; J Seybold; H Schnittler; W Seeger; F Grimminger; K Aktories
Journal:  J Clin Invest       Date:  1991-05       Impact factor: 14.808

Review 2.  Clostridial ADP-ribosyltransferases--modification of low molecular weight GTP-binding proteins and of actin by clostridial toxins.

Authors:  K Aktories
Journal:  Med Microbiol Immunol       Date:  1990       Impact factor: 3.402

3.  Microinjection of ADP-ribosylated actin inhibits actin synthesis in hepatocyte-hepatoma hybrid cells.

Authors:  K H Reuner; A van der Does; P Dunker; I Just; K Aktories; N Katz
Journal:  Biochem J       Date:  1996-11-01       Impact factor: 3.857

Review 4.  Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins.

Authors:  Holger Barth; Klaus Aktories; Michel R Popoff; Bradley G Stiles
Journal:  Microbiol Mol Biol Rev       Date:  2004-09       Impact factor: 11.056

Review 5.  Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins.

Authors:  K Aktories
Journal:  Mol Cell Biochem       Date:  1994-09       Impact factor: 3.396

6.  Development and optimization of a high-throughput assay to measure neutralizing antibodies against Clostridium difficile binary toxin.

Authors:  Jinfu Xie; Melanie Horton; Julie Zorman; Joseph M Antonello; Yuhua Zhang; Beth A Arnold; Susan Secore; Rachel Xoconostle; Matthew Miezeiewski; Su Wang; Colleen E Price; David Thiriot; Aaron Goerke; Marie-Pierre Gentile; Julie M Skinner; Jon H Heinrichs
Journal:  Clin Vaccine Immunol       Date:  2014-03-12

7.  The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes.

Authors:  Julia Eisele; Simone Schreiner; Joscha Borho; Stephan Fischer; Sebastian Heber; Sascha Endres; Maximilian Fellermann; Lisa Wohlgemuth; Markus Huber-Lang; Giorgio Fois; Michael Fauler; Manfred Frick; Holger Barth
Journal:  Front Pharmacol       Date:  2022-02-11       Impact factor: 5.810

Review 8.  Clostridial binary toxins: iota and C2 family portraits.

Authors:  Bradley G Stiles; Darran J Wigelsworth; Michel R Popoff; Holger Barth
Journal:  Front Cell Infect Microbiol       Date:  2011-12-01       Impact factor: 5.293

Review 9.  Clostridium and bacillus binary enterotoxins: bad for the bowels, and eukaryotic being.

Authors:  Bradley G Stiles; Kisha Pradhan; Jodie M Fleming; Ramar Perumal Samy; Holger Barth; Michel R Popoff
Journal:  Toxins (Basel)       Date:  2014-09-05       Impact factor: 4.546
  9 in total

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