Literature DB >> 25082511

Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.

Mohamed-Chiheb Saada1, Daniela Vullo2, Jean-Louis Montero1, Andrea Scozzafava2, Claudiu T Supuran3, Jean-Yves Winum4.   

Abstract

Mono- and di-halogenated histamines, l-histidine methyl ester derivatives and carnosine derivatives incorporating chlorine, bromine and iodine were prepared and investigated as activators of five carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic hCA I, II and VII, and the transmembrane hCA XII and XIV. All of them were activated in a diverse manner by the investigated compounds, with a distinct activation profile.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Activators; Carbonic anhydrases; Halogenated carnosine; Halogenated histamine; Halogenated histidine

Mesh：

Substances：

Year:  2014        PMID： 25082511     DOI： 10.1016/j.bmc.2014.07.005

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

Review 1.  Carbonic Anhydrase Activators for Neurodegeneration: An Overview.

Authors:  Valeria Poggetti; Silvia Salerno; Emma Baglini; Elisabetta Barresi; Federico Da Settimo; Sabrina Taliani
Journal:  Molecules       Date:  2022-04-14       Impact factor: 4.927

2.  Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators.

Authors:  Adriano Mollica; Giorgia Macedonio; Azzurra Stefanucci; Simone Carradori; Atilla Akdemir; Andrea Angeli; Claudiu T Supuran
Journal:  Molecules       Date:  2017-12-09       Impact factor: 4.411

Review 3.  The Human Carbonic Anhydrase II in Platelets: An Underestimated Field of Its Activity.

Authors:  Maciej Jakubowski; Ewa Szahidewicz-Krupska; Adrian Doroszko
Journal:  Biomed Res Int       Date:  2018-06-28       Impact factor: 3.411

4.  (Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators.

Authors:  Marouan Rami; Jean-Yves Winum; Claudiu T Supuran; Patricia Melnyk; Saïd Yous
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

5.  Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives.

Authors:  Gustavo Provensi; Alessio Nocentini; Maria Beatrice Passani; Patrizio Blandina; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

Review 6.  Amine- and Amino Acid-Based Compounds as Carbonic Anhydrase Activators.

Authors:  Andrea Angeli; Emanuela Berrino; Simone Carradori; Claudiu T Supuran; Marzia Cirri; Fabrizio Carta; Gabriele Costantino
Journal:  Molecules       Date:  2021-12-02       Impact factor: 4.411

7.  Activation Effects of Carnosine- and Histidine-Containing Dipeptides on Human Carbonic Anhydrases: A Comprehensive Study.

Authors:  Giulio Vistoli; Giancarlo Aldini; Laura Fumagalli; Clelia Dallanoce; Andrea Angeli; Claudiu T Supuran
Journal:  Int J Mol Sci       Date:  2020-03-04       Impact factor: 5.923

8.  Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators.

Authors:  Alessio Nocentini; Doretta Cuffaro; Lidia Ciccone; Elisabetta Orlandini; Susanna Nencetti; Elisa Nuti; Armando Rossello; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051
  8 in total

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