| Literature DB >> 25080503 |
Johnny S H Kwan1, Yi-Hsiang Hsu2, Ching-Lung Cheung3, Josée Dupuis4, Aude Saint-Pierre5, Joel Eriksson6, Samuel K Handelman7, Aaron Aragaki8, David Karasik9, Peter P Pramstaller10, Charles Kooperberg11, Andrea Z Lacroix12, Martin G Larson4, Kam-Shing Lau3, Mattias Lorentzon6, Irene Pichler13, Pak C Sham14, Daniel Taliun13, Liesbeth Vandenput6, Douglas P Kiel15, Andrew A Hicks13, Rebecca D Jackson8, Claes Ohlsson6, Emelia J Benjamin16, Annie W C Kung17.
Abstract
Osteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured in serum or in plasma. In a meta-analysis of genome-wide association studies in up to 10 336 individuals from European and Asian origin, we discovered that variants >100 kb upstream of the TNFRSF11B gene encoding OPG and another new locus on chromosome 17q11.2 were significantly associated with OPG variation. We also identified a suggestive locus on chromosome 14q21.2 associated with the trait. Moreover, we estimated that over half of the heritability of OPG levels could be explained by all variants examined in our study. Our findings provide further insight into the genetic regulation of circulating OPG levels.Entities:
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Year: 2014 PMID： 25080503 PMCID： PMC4240210 DOI： 10.1093/hmg/ddu386
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150