Literature DB >> 25075750

Shapes of interacting RNA complexes.

Benjamin M M Fu1, Christian M Reidys.   

Abstract

Shapes of interacting RNA complexes are studied using a filtration via their topological genus. A shape of an RNA complex is obtained by (iteratively) collapsing stacks and eliminating hairpin loops. This shape projection preserves the topological core of the RNA complex, and for fixed topological genus there are only finitely many such shapes. Our main result is a new bijection that relates the shapes of RNA complexes with shapes of RNA structures. This allows for computing the shape polynomial of RNA complexes via the shape polynomial of RNA structures. We furthermore present a linear time uniform sampling algorithm for shapes of RNA complexes of fixed topological genus.

Keywords:  bijection; interacting RNA complexes; shape polynomials; topological genus; uniform generation

Mesh:

Substances:

Year:  2014        PMID: 25075750      PMCID: PMC4148064          DOI: 10.1089/cmb.2014.0107

Source DB:  PubMed          Journal:  J Comput Biol        ISSN: 1066-5277            Impact factor:   1.479


  15 in total

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Journal:  Bioessays       Date:  2002-02       Impact factor: 4.345

Review 2.  The expanding snoRNA world.

Authors:  Jean Pierre Bachellerie; Jérôme Cavaillé; Alexander Hüttenhofer
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3.  Topology of RNA-RNA interaction structures.

Authors:  Jørgen E Andersen; Fenix W D Huang; Robert C Penner; Christian M Reidys
Journal:  J Comput Biol       Date:  2012-06-25       Impact factor: 1.479

4.  Shapes of topological RNA structures.

Authors:  Fenix W D Huang; Christian M Reidys
Journal:  Math Biosci       Date:  2015-10-19       Impact factor: 2.144

5.  An RNA transcriptional regulator templates its own regulatory RNA.

Authors:  Jennifer F Kugel; James A Goodrich
Journal:  Nat Chem Biol       Date:  2007-02       Impact factor: 15.040

6.  Topological classification of RNA structures.

Authors:  Michael Bon; Graziano Vernizzi; Henri Orland; A Zee
Journal:  J Mol Biol       Date:  2008-04-18       Impact factor: 5.469

7.  A dynamic programming algorithm for RNA structure prediction including pseudoknots.

Authors:  E Rivas; S R Eddy
Journal:  J Mol Biol       Date:  1999-02-05       Impact factor: 5.469

8.  Topology and prediction of RNA pseudoknots.

Authors:  Christian M Reidys; Fenix W D Huang; Jørgen E Andersen; Robert C Penner; Peter F Stadler; Markus E Nebel
Journal:  Bioinformatics       Date:  2011-02-17       Impact factor: 6.937

9.  Topological classification and enumeration of RNA structures by genus.

Authors:  J E Andersen; R C Penner; C M Reidys; M S Waterman
Journal:  J Math Biol       Date:  2012-10-02       Impact factor: 2.259

Review 10.  RNA-editing in trypanosome mitochondria.

Authors:  R Benne
Journal:  Biochim Biophys Acta       Date:  1989-03-01
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  2 in total

1.  Genus for biomolecules.

Authors:  Paweł Rubach; Sebastian Zajac; Borys Jastrzebski; Joanna I Sulkowska; Piotr Sułkowski
Journal:  Nucleic Acids Res       Date:  2020-01-08       Impact factor: 16.971

2.  Genus trace reveals the topological complexity and domain structure of biomolecules.

Authors:  Sebastian Zając; Cody Geary; Ebbe Sloth Andersen; Pawel Dabrowski-Tumanski; Joanna I Sulkowska; Piotr Sułkowski
Journal:  Sci Rep       Date:  2018-12-03       Impact factor: 4.379

  2 in total

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