Alex V Levin1, Jose A Cordovez1, Benjamin E Leiby1, Edward Pequignot1, Anamika Tandon1. 1. Pediatric Ophthalmology and Ocular Genetics Service, Wills Eye Institute (Dr Levin and Dr Cordovez), the Department of Ophthalmology, Thomas Jefferson University (Dr Levin), and the Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University (Dr Leiby and Mr Pequignot), Philadelphia, Pennsylvania; and Pediatric Ophthalmology, Leicester Royal Infirmary NHS Trust, Leicester, United Kingdom (Dr Tandon).
Abstract
PURPOSE: To assess the performance of a refined Web-based tool for documenting retinal hemorrhage characteristics in suspected abusive head trauma. METHODS: Using a comprehensive tabular secure platform, with access to digital images in color, black and white, and 4-zone system schematic overlay, four pediatric ophthalmologists performed pilot testing with 80 images for tool refinement. In a second phase, retinal hemorrhages were documented by number, zone, and type. Interobserver agreement was calculated using the Fleiss kappa coefficient. Intraobserver agreement was calculated using Cohen's kappa statistic. We used surface area mapping software for further analysis. RESULTS: Interobserver agreement was good (kappa 0.4-0.6) and very good (kappa 0.6-0.8) for all questions in Zone A (peripapillary). For zones C (midperiphery) and D (peripheral retina), agreement was very good for all questions except number of hemorrhages, for which agreement was good. Zone B (macula) showed good and fair agreement except for superficial hemorrhage, for which agreement was poor. There was very good intraobserver agreement for number (kappa 0.68, 0.65, 0.67) and type of hemorrhages in zones A, B, and C. Surface area mapping results revealed no significant differences between zones A and B. Zones C and D had significantly less hemorrhage than A and B. CONCLUSIONS: Our tool performed with good or very good interobserver and intraobserver agreement in almost all domains. We attribute zone B underperformance to the significant increased area covered by hemorrhages compared to zones C and D and the lack of contrast with normal anatomical structures in zone A.
PURPOSE: To assess the performance of a refined Web-based tool for documenting retinal hemorrhage characteristics in suspected abusive head trauma. METHODS: Using a comprehensive tabular secure platform, with access to digital images in color, black and white, and 4-zone system schematic overlay, four pediatric ophthalmologists performed pilot testing with 80 images for tool refinement. In a second phase, retinal hemorrhages were documented by number, zone, and type. Interobserver agreement was calculated using the Fleiss kappa coefficient. Intraobserver agreement was calculated using Cohen's kappa statistic. We used surface area mapping software for further analysis. RESULTS: Interobserver agreement was good (kappa 0.4-0.6) and very good (kappa 0.6-0.8) for all questions in Zone A (peripapillary). For zones C (midperiphery) and D (peripheral retina), agreement was very good for all questions except number of hemorrhages, for which agreement was good. Zone B (macula) showed good and fair agreement except for superficial hemorrhage, for which agreement was poor. There was very good intraobserver agreement for number (kappa 0.68, 0.65, 0.67) and type of hemorrhages in zones A, B, and C. Surface area mapping results revealed no significant differences between zones A and B. Zones C and D had significantly less hemorrhage than A and B. CONCLUSIONS: Our tool performed with good or very good interobserver and intraobserver agreement in almost all domains. We attribute zone B underperformance to the significant increased area covered by hemorrhages compared to zones C and D and the lack of contrast with normal anatomical structures in zone A.
Authors: Kirsten Bechtel; Kathleen Stoessel; John M Leventhal; Eileen Ogle; Barbara Teague; Sylvia Lavietes; Bruna Banyas; Karin Allen; James Dziura; Charles Duncan Journal: Pediatrics Date: 2004-07 Impact factor: 7.124
Authors: M G F Gilliland; Alex V Levin; Robert W Enzenauer; Charles Smith; M Andrew Parsons; Lucy B Rorke-Adams; James R Lauridson; G Robert La Roche; Linda M Christmann; Marcellina Mian; Jeffrey Jentzen; Kenneth B Simons; Yair Morad; Randell Alexander; Carole Jenny; Tamara Wygnanski-Jaffe Journal: Am J Forensic Med Pathol Date: 2007-12 Impact factor: 0.921
Authors: Angell Shi; Abhaya Kulkarni; Kenneth W Feldman; Avery Weiss; Emily A McCourt; Susan Schloff; Michael Partington; Brian Forbes; Brooke E Geddie; Karin Bierbrauer; Paul H Phillips; David L Rogers; Waleed Abed Alnabi; Gil Binenbaum; Alex V Levin Journal: Pediatrics Date: 2019-01-10 Impact factor: 7.124