Literature DB >> 25074273

Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene.

Mustafa Solak1, Mujgan Ozdemir Erdogan, Saliha Handan Yildiz, Kagan Ucok, Seref Yuksel, Evrim Suna Arıkan Terzi, Ahmet Bestepe.   

Abstract

The aim of this study is to investigate the genetic influence of polymorphisms in fat mass and obesity associated (FTO) gene on a sample of obese subjects and controls. Obesity is an epidemic all over the world. Several polymorphisms in the first intron of FTO gene have been associated with common forms of human obesity. In this research rs1421085 and rs9939609 polymorphisms of FTO gene were genotyped in 190 obese patients with a BMI ≥30 kg/m(2) (Body Mass Index) and 97 healthy controls with a BMI of 18.5-24.9. Genotyping of SNPs was performed by real-time polymerase chain reaction. Body composition was established with bioelectric impedance analysis. Waist-to-hip ratio was determined for all participants. There were no significant differences (P > 0.05) between obese cases and controls in terms of genotype frequencies of rs1421085 and rs9939609 polymorphisms in our study. Also there were no significant correlations between genotypes and obesity related (anthropometric-body composition) parameters (P > 0.05).

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Year:  2014        PMID： 25074273     DOI： 10.1007/s11033-014-3627-2

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  29 in total

1.  Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations.

Authors:  Wei Huang; Yanlei Sun; Jiazhong Sun
Journal:  Endocrine       Date:  2010-11-10       Impact factor: 3.633

2.  Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population.

Authors:  Huaixing Li; Ying Wu; Ruth J F Loos; Frank B Hu; Yong Liu; Jing Wang; Zhijie Yu; Xu Lin
Journal:  Diabetes       Date:  2007-10-24       Impact factor: 9.461

3.  FTO polymorphisms in oceanic populations.

Authors:  Jun Ohashi; Izumi Naka; Ryosuke Kimura; Kazumi Natsuhara; Taro Yamauchi; Takuro Furusawa; Minato Nakazawa; Yuji Ataka; Jintana Patarapotikul; Pornlada Nuchnoi; Katsushi Tokunaga; Takafumi Ishida; Tsukasa Inaoka; Yasuhiro Matsumura; Ryutaro Ohtsuka
Journal:  J Hum Genet       Date:  2007-10-11       Impact factor: 3.172

4.  The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression.

Authors:  Z Samaan; S S Anand; S Anand; X Zhang; D Desai; M Rivera; G Pare; L Thabane; C Xie; H Gerstein; J C Engert; I Craig; S Cohen-Woods; V Mohan; R Diaz; X Wang; L Liu; T Corre; M Preisig; Z Kutalik; S Bergmann; P Vollenweider; G Waeber; S Yusuf; D Meyre
Journal:  Mol Psychiatry       Date:  2012-11-20       Impact factor: 15.992

5.  Prevalence of overweight and obesity in the United States, 1999-2004.

Authors:  Cynthia L Ogden; Margaret D Carroll; Lester R Curtin; Margaret A McDowell; Carolyn J Tabak; Katherine M Flegal
Journal:  JAMA       Date:  2006-04-05       Impact factor: 56.272

6.  An obesity-associated FTO gene variant and increased energy intake in children.

Authors:  Joanne E Cecil; Roger Tavendale; Peter Watt; Marion M Hetherington; Colin N A Palmer
Journal:  N Engl J Med       Date:  2008-12-11       Impact factor: 91.245

Review 7.  From monogenic to polygenic obesity: recent advances.

Authors:  Anke Hinney; Carla I G Vogel; Johannes Hebebrand
Journal:  Eur Child Adolesc Psychiatry       Date:  2010-02-03       Impact factor: 4.785

8.  A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

Authors:  Timothy M Frayling; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Rachel M Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy
Journal:  Science       Date:  2007-04-12       Impact factor: 47.728

9.  The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924.

Authors:  Josefin A Jacobsson; Ulf Risérus; Tomas Axelsson; Lars Lannfelt; Helgi B Schiöth; Robert Fredriksson
Journal:  BMC Med Genet       Date:  2009-12-09       Impact factor: 2.103

10.  Polymorphisms in FTO and MAF Genes and Birth Weight, BMI, Ponderal Index, Weight Gain in a Large Cohort of Infants with a Birth Weight below 1500 Grams.

Authors:  Sebastian Haller; Juliane Spiegler; Claudia Hemmelmann; Helmut Küster; Matthias Vochem; Jens Möller; Dirk Müller; Angela Kribs; Thomas Hoehn; Christoph Härtel; Egbert Herting; Wolfgang Göpel
Journal:  PLoS One       Date:  2013-06-26       Impact factor: 3.240
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  4 in total

1.  Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents.

Authors:  Nihal Inandiklioğlu; Adem Yaşar
Journal:  J Pediatr Genet       Date:  2020-06-10

2.  Differential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population.

Authors:  Erasmo Saucedo-Uribe; Alma Delia Genis-Mendoza; Adriana Díaz-Anzaldúa; José Jaime Martínez-Magaña; Carlos Alfonso Tovilla-Zarate; Isela Juárez-Rojop; Nuria Lanzagorta; Michael Escamilla; Thelma Beatriz González-Castro; María Lilia López Narvaez; Yazmín Hernández-Díaz; Humberto Nicolini
Journal:  Brain Behav       Date:  2019-04-29       Impact factor: 2.708

3.  The association between FTO rs9939609 gene polymorphism and anthropometric indices in adults.

Authors:  Mahsa Mehrdad; Majid Fardaei; Mohammad Fararouei; Mohammad Hassan Eftekhari
Journal:  J Physiol Anthropol       Date:  2020-05-12       Impact factor: 2.867

4.  Relationship Between Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms with Obesity and Metabolic Syndrome in Ethnic Mongolians.

Authors:  Qiang Zhang; Xiayun Xia; Shixin Fang; Xiangzhen Yuan
Journal:  Med Sci Monit       Date:  2018-11-16
  4 in total

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