| Literature DB >> 17928949 |
Jun Ohashi1, Izumi Naka2, Ryosuke Kimura3, Kazumi Natsuhara4, Taro Yamauchi5, Takuro Furusawa6, Minato Nakazawa7, Yuji Ataka8, Jintana Patarapotikul9, Pornlada Nuchnoi9, Katsushi Tokunaga2, Takafumi Ishida10, Tsukasa Inaoka11, Yasuhiro Matsumura12, Ryutaro Ohtsuka13.
Abstract
It has been suggested that Neel's "thrifty genotype" model may account for high body weights in some Oceanic populations, which presumably arose in modern times. In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity. In this study, we investigated the population frequencies of these variants in six Oceanic populations (Melanesians, Micronesians, and Polynesians) and tested for an association with BMI. Unlike European populations, the Oceanic populations displayed no significant association between the FTO polymorphisms and BMI. These variants were in strong linkage disequilibrium. The population frequencies ranged between 4.2 and 30.3% in the six Oceanic populations, and were similar to those in southeast and east Asian populations. Our study of the FTO polymorphisms has generated no evidence to support the thrifty genotype hypothesis for Oceanic populations.Entities:
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Year: 2007 PMID： 17928949 DOI： 10.1007/s10038-007-0198-2
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172