The role of antiproliferative gene Tob1 in the immune system.

Tob1 (transducer of ERBB2-1, TOB1 is humans) is a member of the antiproliferative (APRO) family of proteins that controls cell cycle progression in several cell types. In addition, Tob1 has been implicated in diverse cellular mechanisms such as embryonic dorsal development, and T helper 17 (Th17) cell function. More recently, evidence linking Tob1 function to experimental and human immune related disorders has mounted, thus underscoring the potential of this molecule as a biomarker and as a therapeutic target. This article reviews these functions with an emphasis on their implications for human autoimmune diseases such as multiple sclerosis.