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Literature DB >> 25070879

Cysteine-selective reactions for antibody conjugation.

Pedro M S D Cal¹, Gonçalo J L Bernardes, Pedro M P Gois.

Abstract

Moving tracks from maleimide: New site-selective protein modification reactions at cysteine have been developed. Unlike conventional maleimide conjugation, which results in a labile thioether succinimide, the new bioconjugation reactions result in stable conjugates and provide opportunities to develop a new generation of homogeneous, stable, and therapeutically useful conjugates.

Entities: Chemical

Keywords: antibodies; bioorganic chemistry; conjugation; drug delivery; maleimides

Mesh：

Substances：

Year: 2014 PMID： 25070879 DOI： 10.1002/anie.201405702

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

28 in total

1. A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins.

Authors: Joseph J Bellucci; Jayanta Bhattacharyya; Ashutosh Chilkoti
Journal: Angew Chem Int Ed Engl Date: 2014-10-31 Impact factor: 15.336

10. Computation-Guided Rational Design of a Peptide Motif That Reacts with Cyanobenzothiazoles via Internal Cysteine-Lysine Relay.

Authors: Samantha G L Keyser; Ashley Utz; Carolyn R Bertozzi
Journal: J Org Chem Date: 2018-05-30 Impact factor: 4.354

Cysteine-selective reactions for antibody conjugation.

1. A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins.

2. Protein modification: Standing out from the crowd.

3. A little less conjugation, a little more accuracy.

4. Site-selective protein-modification chemistry for basic biology and drug development.

5. Organometallic Gold(III) Reagents for Cysteine Arylation.

6. Fast, irreversible modification of cysteines through strain releasing conjugate additions of cyclopropenyl ketones.

Review 7. Bifunctional chelators for radiorhenium: past, present and future outlook.

8. Fast and Cysteine-Specific Modification of Peptides, Proteins and Bacteriophage Using Chlorooximes.

9. Assessment of reagents for selenocysteine conjugation and the stability of selenocysteine adducts.

10. Computation-Guided Rational Design of a Peptide Motif That Reacts with Cyanobenzothiazoles via Internal Cysteine-Lysine Relay.