| Literature DB >> 25069084 |
Wenjun Zhang1, Liang Ma1, Sumei Li1, Zhong Liu2, Yuchan Chen3, Haibo Zhang1, Guangtao Zhang1, Qingbo Zhang1, Xinpeng Tian1, Chengshan Yuan1, Si Zhang1, Weimin Zhang3, Changsheng Zhang1.
Abstract
Five new bisindole alkaloids, indimicins A-E (1-5), bearing a unique 1',3'-dimethyl-2'-hydroindole moiety, were isolated from the marine-derived Streptomyces sp. SCSIO 03032, along with two new compounds, lynamicins F and G (6 and 7). Their planar structures were elucidated by detailed interpretation of their MS and NMR spectroscopic data, and the absolute configurations were determined by X-ray crystallographic analysis (for 1), comparison of CD spectra (for 2-4), and quantum chemical calculations (for 5). Indimicin B (2) exhibited moderate cytotoxic activity toward the MCF-7 cell line.Entities:
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Year: 2014 PMID： 25069084 DOI： 10.1021/np500362p
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050