Large-cell neuroendocrine carcinoma of the lung: surgical management.

Large-cell neuroendocrine carcinoma (LCNEC) of the lung is an uncommon aggressive neoplasm with a poor prognosis compared with non-small-cell lung carcinoma (NSCLC). Because of its rarity, the treatment recommendations are not based on clinical trials, but are extrapolated from the approach to patients with NSCLC and small-cell lung carcinoma and the established literature for LCNEC, which is primarily retrospective in nature. Further studies should clarify the histology-specific characteristic and optimal therapeutic approach to establish the entity of LCNEC.