S E Mous1, R L Muetzel1, H El Marroun1, T J C Polderman2, A van der Lugt3, V W Jaddoe1, A Hofman4, F C Verhulst5, H Tiemeier5, D Posthuma5, T White5. 1. The Generation R Study Group,Erasmus Medical Center,Rotterdam,The Netherlands. 2. Complex Trait Genetics, Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam (NCA),VU University,Amsterdam,The Netherlands. 3. Department of Radiology,Erasmus Medical Center,Rotterdam,The Netherlands. 4. Department of Epidemiology,Erasmus Medical Center,Rotterdam,The Netherlands. 5. Department of Child and Adolescent Psychiatry/Psychology,Erasmus Medical Center - Sophia Children's Hospital,Rotterdam,The Netherlands.
Abstract
BACKGROUND: While many neuroimaging studies have investigated the neurobiological basis of attention deficit hyperactivity disorder (ADHD), few have studied the neurobiology of attention problems in the general population. The ability to pay attention falls along a continuum within the population, with children with ADHD at one extreme of the spectrum and, therefore, a dimensional perspective of evaluating attention problems has an added value to the existing literature. Our goal was to investigate the relationship between cortical thickness and inattention and hyperactivity symptoms in a large population of young children. METHOD: This study is embedded within the Generation R Study and includes 6- to 8-year-old children (n = 444) with parent-reported attention and hyperactivity measures and high-resolution structural imaging data. We investigated the relationship between cortical thickness across the entire brain and the Child Behavior Checklist Attention Deficit Hyperactivity Problems score. RESULTS: We found that greater attention problems and hyperactivity were associated with a thinner right and left postcentral gyrus. When correcting for potential confounding factors and multiple testing, these associations remained significant. CONCLUSIONS: In a large, population-based sample we showed that young (6- to 8-year-old) children who show more attention problems and hyperactivity have a thinner cortex in the region of the right and left postcentral gyrus. The postcentral gyrus, being the primary somatosensory cortex, reaches its peak growth early in development. Therefore, the thinner cortex in this region may reflect either a deviation in cortical maturation or a failure to reach the same peak cortical thickness compared with children without attention or hyperactivity problems.
BACKGROUND: While many neuroimaging studies have investigated the neurobiological basis of attention deficit hyperactivity disorder (ADHD), few have studied the neurobiology of attention problems in the general population. The ability to pay attention falls along a continuum within the population, with children with ADHD at one extreme of the spectrum and, therefore, a dimensional perspective of evaluating attention problems has an added value to the existing literature. Our goal was to investigate the relationship between cortical thickness and inattention and hyperactivity symptoms in a large population of young children. METHOD: This study is embedded within the Generation R Study and includes 6- to 8-year-old children (n = 444) with parent-reported attention and hyperactivity measures and high-resolution structural imaging data. We investigated the relationship between cortical thickness across the entire brain and the Child Behavior Checklist Attention Deficit Hyperactivity Problems score. RESULTS: We found that greater attention problems and hyperactivity were associated with a thinner right and left postcentral gyrus. When correcting for potential confounding factors and multiple testing, these associations remained significant. CONCLUSIONS: In a large, population-based sample we showed that young (6- to 8-year-old) children who show more attention problems and hyperactivity have a thinner cortex in the region of the right and left postcentral gyrus. The postcentral gyrus, being the primary somatosensory cortex, reaches its peak growth early in development. Therefore, the thinner cortex in this region may reflect either a deviation in cortical maturation or a failure to reach the same peak cortical thickness compared with children without attention or hyperactivity problems.
Authors: Martine Hoogman; Ryan Muetzel; Joao P Guimaraes; Elena Shumskaya; Maarten Mennes; Marcel P Zwiers; Neda Jahanshad; Gustavo Sudre; Thomas Wolfers; Eric A Earl; Juan Carlos Soliva Vila; Yolanda Vives-Gilabert; Sabin Khadka; Stephanie E Novotny; Catharina A Hartman; Dirk J Heslenfeld; Lizanne J S Schweren; Sara Ambrosino; Bob Oranje; Patrick de Zeeuw; Tiffany M Chaim-Avancini; Pedro G P Rosa; Marcus V Zanetti; Charles B Malpas; Gregor Kohls; Georg G von Polier; Jochen Seitz; Joseph Biederman; Alysa E Doyle; Anders M Dale; Theo G M van Erp; Jeffery N Epstein; Terry L Jernigan; Ramona Baur-Streubel; Georg C Ziegler; Kathrin C Zierhut; Anouk Schrantee; Marie F Høvik; Astri J Lundervold; Clare Kelly; Hazel McCarthy; Norbert Skokauskas; Ruth L O'Gorman Tuura; Anna Calvo; Sara Lera-Miguel; Rosa Nicolau; Kaylita C Chantiluke; Anastasia Christakou; Alasdair Vance; Mara Cercignani; Matt C Gabel; Philip Asherson; Sarah Baumeister; Daniel Brandeis; Sarah Hohmann; Ivanei E Bramati; Fernanda Tovar-Moll; Andreas J Fallgatter; Bernd Kardatzki; Lena Schwarz; Anatoly Anikin; Alexandr Baranov; Tinatin Gogberashvili; Dmitry Kapilushniy; Anastasia Solovieva; Hanan El Marroun; Tonya White; Georgii Karkashadze; Leyla Namazova-Baranova; Thomas Ethofer; Paulo Mattos; Tobias Banaschewski; David Coghill; Kerstin J Plessen; Jonna Kuntsi; Mitul A Mehta; Yannis Paloyelis; Neil A Harrison; Mark A Bellgrove; Tim J Silk; Ana I Cubillo; Katya Rubia; Luisa Lazaro; Silvia Brem; Susanne Walitza; Thomas Frodl; Mariam Zentis; Francisco X Castellanos; Yuliya N Yoncheva; Jan Haavik; Liesbeth Reneman; Annette Conzelmann; Klaus-Peter Lesch; Paul Pauli; Andreas Reif; Leanne Tamm; Kerstin Konrad; Eileen Oberwelland Weiss; Geraldo F Busatto; Mario R Louza; Sarah Durston; Pieter J Hoekstra; Jaap Oosterlaan; Michael C Stevens; J Antoni Ramos-Quiroga; Oscar Vilarroya; Damien A Fair; Joel T Nigg; Paul M Thompson; Jan K Buitelaar; Stephen V Faraone; Philip Shaw; Henning Tiemeier; Janita Bralten; Barbara Franke Journal: Am J Psychiatry Date: 2019-04-24 Impact factor: 18.112
Authors: Sabine E Mous; Tonya White; Ryan L Muetzel; Hanan El Marroun; Jolien Rijlaarsdam; Tinca J C Polderman; Vincent W Jaddoe; Frank C Verhulst; Danielle Posthuma; Henning Tiemeier Journal: J Psychiatry Neurosci Date: 2017-03 Impact factor: 6.186
Authors: Cheima Bouziane; Matthan W A Caan; Hyke G H Tamminga; Anouk Schrantee; Marco A Bottelier; Michiel B de Ruiter; Sandra J J Kooij; Liesbeth Reneman Journal: Neuroimage Clin Date: 2017-09-29 Impact factor: 4.881
Authors: Tonya White; Ryan L Muetzel; Hanan El Marroun; Laura M E Blanken; Philip Jansen; Koen Bolhuis; Desana Kocevska; Sabine E Mous; Rosa Mulder; Vincent W V Jaddoe; Aad van der Lugt; Frank C Verhulst; Henning Tiemeier Journal: Eur J Epidemiol Date: 2017-10-24 Impact factor: 8.082
Authors: Mónica López-Vicente; Joan Forns; Elisabet Suades-González; Mikel Esnaola; Raquel García-Esteban; Mar Álvarez-Pedrerol; Jordi Júlvez; Miguel Burgaleta; Núria Sebastián-Gallés; Jordi Sunyer Journal: Front Psychol Date: 2016-05-13
Authors: Rocio E Gonzalez-Castañeda; Alma Y Galvez-Contreras; Carlos J Martínez-Quezada; Fernando Jauregui-Huerta; Joaquin Grcia-Estrada; Rodrigo Ramos-Zuñiga; Sonia Luquin; Oscar Gonzalez-Perez Journal: Exp Anim Date: 2015-11-06
Authors: Carolyn D Langen; Ryan Muetzel; Laura Blanken; Aad van der Lugt; Henning Tiemeier; Frank Verhulst; Wiro J Niessen; Tonya White Journal: Brain Behav Date: 2018-06-30 Impact factor: 2.708