Literature DB >> 25064448

Malonyldialdehyde and glyoxal act differently on low-density lipoproteins and endotheliocytes.

Elena M Kumskova1, Olga A Antonova, Sergey A Balashov, Alla K Tikhaze, Arthur M Melkumyants, Vadim Z Lankin.   

Abstract

Under some pathological conditions, the natural dicarbonyl compounds can accumulate in the blood. The examples are malonyldialdehyde (MDA) formed as a secondary product of lipid peroxidation of unsaturated fatty acids during atherosclerosis, and glyoxal (GOX), a homolog of MDA, which accumulates during glucose autoxidation in patients with diabetes mellitus. This study compared the influence of both dicarbonyl compounds on low-density lipoproteins (LDL) and the membrane of endotheliocytes. In comparison with GOX, MDA induced more pronounced changes in physical and chemical properties of LDL particles. On the other hand, GOX-modified LDL particles were more prone to oxidation and aggregation than MDA-modified LDL. Incubation of endotheliocytes with MDA increased cell mechanical stiffness in contrast to incubation with GOX, which decreased it.

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Year:  2014        PMID： 25064448     DOI： 10.1007/s11010-014-2144-x

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  24 in total

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  3 in total

1.  Influence of dicarbonyls on kinetic characteristics of glutathione peroxidase.

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Journal:  Oxid Med Cell Longev       Date:  2017-10-02       Impact factor: 6.543
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