Felipe A Calvo1, Morena Sallabanda2, Claudio V Sole1, Carmen Gonzalez3, Laura Alonso Murillo2, Javier Martinez-Villanueva2, Juan A Santos4, Javier Serrano5, Ana Alavrez5, Jose Blanco5, Ana Calin5, Marina Gomez-Espi5, Miguel Lozano5, Rafael Herranz5. 1. Department of Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain ; School of Medicine Complutense University, Madrid, Spain ; Institute for Sanitary Research, Hospital General Universitario Gregorio Marañón, Madrid, Spain. 2. School of Medicine Complutense University, Madrid, Spain. 3. School of Medicine Complutense University, Madrid, Spain ; Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain. 4. Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain ; Institute for Sanitary Research, Hospital General Universitario Gregorio Marañón, Madrid, Spain. 5. Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Abstract
BACKGROUND: Intraoperative radiotherapy (IORT) refers to the delivery of a high dose of radiation at the time of surgery. AIM: To analyze clinical and research-oriented innovative activities developed in a 17-year period using intraoperative electron-radiation therapy (IOeRT) as a component of treatment in a multidisciplinary approach for cancer management. MATERIALS AND METHODS: From 01/1995 to 03/2012 IOeRT procedures were registered in a specific Hospital-based database. Research and developments in imaging and recording for treatment planning implementation are active since 2006. RESULTS: 1004 patients were treated and 1036 IORT procedures completed. Median age of patients was 61 (range 5 months to 94 years). Gender distribution was male in 54% of cases and female in 46%. Disease status at the time of IORT was 796 (77%) primary and 240 (23%) recurrent. Cancer type distribution included: 62% gastrointestinal, 18% sarcoma, 5% pancreas, 2% paediatric, 3% breast, 77 7% oligotopic recurrences, 2% other. IORT technical characteristics were: Applicator size 5 cm 22%, 6 cm 21%, 7 cm 21%, 8 cm 15%, 9 cm 6%, 10 cm 7% 12 cm 5% 15 cm 3%. Electron energies: 6 MeV 19%, 8 MeV 15%, 10 MeV 15%, 12 MeV 23%, 15 MeV 19%, 18 MeV 6%, other 3%. Multiple fields: 108 (11%). Dose: 7.5 Gy 3%, 10 Gy 35%, 12 Gy 3%, 12.5 Gy 49%, 15 Gy 5%, other 5%. CONCLUSION: An IORT programme developed in an Academic Hospital based on practice-oriented medical decisions is an attractive interdisciplinary oncology initiative proven to be able to generate an intensive clinical activity for cancer patient quality care and a competitive source of scientific patient-oriented research, development and innovation.
BACKGROUND: Intraoperative radiotherapy (IORT) refers to the delivery of a high dose of radiation at the time of surgery. AIM: To analyze clinical and research-oriented innovative activities developed in a 17-year period using intraoperative electron-radiation therapy (IOeRT) as a component of treatment in a multidisciplinary approach for cancer management. MATERIALS AND METHODS: From 01/1995 to 03/2012 IOeRT procedures were registered in a specific Hospital-based database. Research and developments in imaging and recording for treatment planning implementation are active since 2006. RESULTS: 1004 patients were treated and 1036 IORT procedures completed. Median age of patients was 61 (range 5 months to 94 years). Gender distribution was male in 54% of cases and female in 46%. Disease status at the time of IORT was 796 (77%) primary and 240 (23%) recurrent. Cancer type distribution included: 62% gastrointestinal, 18% sarcoma, 5% pancreas, 2% paediatric, 3% breast, 77 7% oligotopic recurrences, 2% other. IORT technical characteristics were: Applicator size 5 cm 22%, 6 cm 21%, 7 cm 21%, 8 cm 15%, 9 cm 6%, 10 cm 7% 12 cm 5% 15 cm 3%. Electron energies: 6 MeV 19%, 8 MeV 15%, 10 MeV 15%, 12 MeV 23%, 15 MeV 19%, 18 MeV 6%, other 3%. Multiple fields: 108 (11%). Dose: 7.5 Gy 3%, 10 Gy 35%, 12 Gy 3%, 12.5 Gy 49%, 15 Gy 5%, other 5%. CONCLUSION: An IORT programme developed in an Academic Hospital based on practice-oriented medical decisions is an attractive interdisciplinary oncology initiative proven to be able to generate an intensive clinical activity for cancerpatient quality care and a competitive source of scientific patient-oriented research, development and innovation.
Entities:
Keywords:
Database; Intraoperative radiation therapy; Research
Authors: Felipe A Calvo; Marina Gómez-Espí; Juan A Díaz-González; Arnaldo Alvarado; Rocío Cantalapiedra; Pilar Marcos; Raúl Matute; Nuria E Martínez; Miguel A Lozano; Rafael Herranz Journal: Radiother Oncol Date: 2002-02 Impact factor: 6.280
Authors: Robert Krempien; Falk Roeder; Susanne Oertel; Marianne Roebel; Jürgen Weitz; Frank W Hensley; Carmen Timke; Angela Funk; Marc Bischof; Angelika Zabel-Du Bois; Andreas G Niethammer; Michael J Eble; Markus W Buchler; Martina Treiber; Jürgen Debus Journal: Int J Radiat Oncol Biol Phys Date: 2006-09-18 Impact factor: 7.038
Authors: Vincenzo Valentini; Felipe Calvo; Michele Reni; Robert Krempien; Felix Sedlmayer; Markus W Buchler; Valerio Di Carlo; Giovanni B Doglietto; Gerd Fastner; José L Garcia-Sabrido; GianCarlo Mattiucci; Alessio G Morganti; Paolo Passoni; Falk Roeder; Giuseppe R D'Agostino Journal: Radiother Oncol Date: 2008-08-30 Impact factor: 6.280
Authors: Juan López-Tarjuelo; Ana Bouché-Babiloni; Virginia Morillo-Macías; Agustín Santos-Serra; Carlos Ferrer-Albiach Journal: Rep Pract Oncol Radiother Date: 2016-10-19
Authors: Fa Calvo; Cv Sole; R Herranz; M Lopez-Bote; J Pascau; A Santos; A Muñoz-Calero; C Ferrer; Jl Garcia-Sabrido Journal: Ecancermedicalscience Date: 2013-08-15
Authors: Felipe A Calvo; Javier Serrano; Mauricio Cambeiro; Javier Aristu; Jose Manuel Asencio; Isabel Rubio; Jose Miguel Delgado; Carlos Ferrer; Manuel Desco; Javier Pascau Journal: Cancers (Basel) Date: 2022-07-29 Impact factor: 6.575